Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water  

作　　者：Qinli Lu Xianming Wang Wanliu Wen Ruifeng Fan Binfeng Zhu Bingjie Zhou Jingchao Chen Baomin Fan 

机构地区：[1]Key Laboratory of Chemistry in Ethnic Medicinal Resources(Yunnan Minzu University),State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University,Kunming,650500,China [2]Department School of Chemistry and Environment,Yunnan Minzu University,Kunming 650500,China [3]School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China

出　　处：《Green Synthesis and Catalysis》2024年第3期175-179,共5页绿色合成与催化（英文）

基　　金：grateful to the National Natural Science Foundation of China(Nos.21961045 and 22061048);the Basic Research Project of Chongqing Academy of Chinese Materia Medica(No.jbky20190028);the Fund Project of Yunnan Key Laboratory of Pharmacology for Natural Products(No.YKLPNP-K2303);Yunnan Provincial Key Laboratory Construction Plan Funding of Universities;Yunnan Provincial Engineering Research Center Construction Plan Funding of Universities for their financial support.

摘　　要：The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized compounds.Herein,the asymmetric reduction ofα,β-unsaturated nitriles with water as a hydrogen source is reported.The reaction is catalyzed by the complex of[Ir(COD)Cl]_(2)and(R_(a),S)-Ph-Bn-SiPhox,and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.

关 键 词：Asymmetric reduction Unsaturated nitriles WATER PROPIONITRILE IRIDIUM DIBAL-H 

分 类 号：O62[理学—有机化学]