Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation  

作　　者：Zhenhua Liu Xiaoqing Xu Zhenhua Liang Yixiao Chen Qiuyi Wang Wenyi Kang Yan Zhang Bin Cong 

机构地区：[1]National R&D Center for Edible Fungus Processing Technology,Henan University,Kaifeng 475004,China [2]Joint International Research Laboratory of Food&Medicine Resource Function,Kaifeng 475004,China [3]College of Agriculture,Henan University,Kaifeng 475004,China [4]Shenzhen Research Institute of Henan University,Shenzhen 518000,China [5]Hebei Key Laboratory of Forensic Medicine,College of Forensic Medicine,Hebei Medical University,Shijiazhuang 050017,China [6]Hebei Food Safety Key Laboratory,Hebei Food Inspection and Research Institute,Shijiazhuang 050091,China

出　　处：《Food Science and Human Wellness》2024年第6期3159-3170,共12页食品科学与人类健康（英文）

基　　金：supported by National Key R&D Program of China(2022YFF1100300);the Central Guidance on Local Science and Technology Development Found of Shenzhen,China(2021Szvup030).

摘　　要：Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes.Therefore,it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation.Here,we present evidence that Bakuchiol(BL),a monoterpene phenolic compound first discovered from Psoralea corylifolia L.as traditional Chinese medicine,can effectively improve insulin resistance in diabetic mice through anti-inflammation.Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4/nuclear factorκB/mitogen-activated protein kinase axis,consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substrate1 pathway and improving glucolipid homeostasis.Furthermore,the insulin recovery achieved with BL(60 mg/kg)was comparable to that of metformin(200 mg/kg).These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus.

关 键 词：BAKUCHIOL DIABETES Insulin resistance PROTEOMIC INFLAMMATION 

分 类 号：TS201.4[轻工技术与工程—食品科学] R587.1[轻工技术与工程—食品科学与工程]