靶向蛋白质组学技术在食品安全检测的应用  

Application of Targeted Proteomics in Food Safety Detection

作　　者：陈梦琪 彭淼曦 刘婧文 黄成栋 吴祖庆 凌莉 袁慕云 陈文锐 胡松青 CHEN Mengqi;PENG Miaoxi;LIU Jingwen;HUANG Chengdong;WU Zuqing;LING Li;YUAN Muyun;CHEN Wenrui;HU Songqing(School of Food Science and Engineering,South China University of Technology,Guangzhou 510641,China;Guangzhou Customs Technology Center,Guangzhou 510623,China)

机构地区：[1]华南理工大学食品科学与工程学院,广东广州510641 [2]广州海关技术中心,广东广州510623

出　　处：《食品科学》2024年第23期297-310,共14页Food Science

基　　金：“十四五”国家重点研发计划重点专项(2022YFF1100805)。

摘　　要：食品安全是关乎国民健康的重大公共卫生问题。基于质谱的靶向蛋白质组学凭借其灵敏度高、特异性强和定量准确性好等优势,在评估食品安全方面发挥着越来越重要的作用。本文首先介绍多反应监测和平行反应监测两种常见的靶向蛋白质组学技术;重点综述近5年靶向蛋白质组学技术在食品安全检测领域的最新研究进展,主要涉及动物源性食品掺假鉴别、食物过敏原检测和食源性致病菌及其毒素检测;最后对该领域未来发展进行展望。Food safety is a major global public health concern.Targeted proteomics based on mass spectrometry(MS)plays an increasingly important role in addressing this issue due to its high sensitivity,specificity,and quantitative accuracy.In this article,two common targeted proteomics approaches including multiple reaction monitoring(MRM)and parallel reaction monitoring(PRM)are briefly introduced.The progress that has been made in the application of targeted proteomics in food safety detection in the last five years is summarized including authentication of animal-derived foods,analysis of food allergens,and detection of foodborne pathogens and their toxins.Meanwhile,an outlook on the future development of this field is given.

关 键 词：靶向蛋白质组学 食品安全 多反应监测 平行反应监测 

分 类 号：TS207.3[轻工技术与工程—食品科学]