基于microRNA共调控网络的植物多酚调节机体活性研究进展  

Research Progress on Plant Polyphenols for Regulation of Body Activity Based on MicroRNA Co-regulatory Network

作　　者：王丹[1] 李大鹏[2] WANG Dan;LI Dapeng(Shandong Institute of Pomology,Taian 271000,China;College of Food Science and Engineering,Shandong Agricultural University,Taian 271018,China)

机构地区：[1]山东省果树研究所,山东泰安271000 [2]山东农业大学食品科学与工程学院,山东泰安271018

出　　处：《食品与生物技术学报》2024年第8期11-19,30,共10页Journal of Food Science and Biotechnology

基　　金：山东省自然科学基金项目(ZR2022QC012)。

摘　　要：植物多酚是人类膳食中含量最丰富的抗氧化剂之一,它们通过与细胞信号级联反应相互作用、调节转录因子的活性,从而参与机体活性的调控。此外,多酚已被证明可以影响microRNA(miRNA)的表达。miRNA能参与大多数的细胞分化和稳态过程,在许多病理中发挥着重要作用。近年来,网络生物学的发展促进了人们对miRNA控制的相互交织调控网络的理解。作者综述了共表达miRNA在信号网络中的特征和作用模式,以及miRNA与转录因子之间复杂且有序的关系;总结了单一和多个miRNA介导植物多酚参与调节机体心血管疾病、糖尿病、炎症和癌症的作用机制,有助于更全面、准确地揭示植物多酚等食品营养与健康因子调控生理功能的实际情况。Plant polyphenols are one of the most abundant antioxidants in human diets,which are involved in the regulation of body activity by interacting with cell signaling cascade and regulating the activity of transcription factors.In addition,polyphenols have been shown to influence microRNA(miRNA)expression.Moreover,miRNA can participate in most cell differentiation and homeostasis,playing an important role in many pathological.In recent years,advances in network-biology have fuelled our understanding of the regulatory networks controlled by multiple miRNA.In this paper,we have discussed the characteristics and mode of co-expressing miRNA in signal networks along with the complex and ordered relationship between miRNA and transcription factors.We also summarized the mechanism of action of single and multiple miRNA mediating plant polyphenols in regulating cardiovascular diseases,diabetes,inflammation and cancer,which is thought to help reveal more comprehensively and accurately the actual situation of plant polyphenols and other food nutrition and health factors in regulating physiological functions.

关 键 词：MICRORNA 机体健康 植物多酚 网络调控 协同作用 

分 类 号：TS201.4[轻工技术与工程—食品科学]