茶叶提取物表没食子儿茶素没食子酸酯的抗纤维化研究进展  

Research progress on anti-fibrosis of epigallocatechin gallate in tea extract

作　　者：薛颖 李雄 陈芬荣[1] 史海涛[1] 李红[1] 赵刚[1] XUE Ying;LI Xiong;CHEN Fenrong;SHI Haitao;LI Hong;ZHAO Gang(Department of Gastroenterology,the Second Hospital of Xi′an Jiaotong University,Xi′an 710004,China)

机构地区：[1]西安交通大学第二附属医院消化内科,陕西西安710004

出　　处：《胃肠病学和肝病学杂志》2024年第12期1716-1722,共7页Chinese Journal of Gastroenterology and Hepatology

基　　金：陕西省重点研发计划一般项目(2021SF-224)。

摘　　要：表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是茶叶提取物中多酚类最主要也是最重要的单体物质。研究表明,EGCG具有抗炎、抗氧化、抗代谢性疾病及抗肿瘤等作用,同时还对心血管及神经系统具有重要的保护作用。器官纤维化是许多疾病发生和发展的重要过程,早期诊断和干预器官纤维化可以有效逆转疾病并改善不良结局。研究表明,EGCG可能通过抗氧化应激、抗炎、抗胶原生成及沉积、抗星状细胞增殖活化等多种途径来抑制纤维化的发生和发展。鉴于EGCG在抗器官纤维化方面可能具有重要的临床应用价值,本文将对EGCG在器官纤维化中的作用进行综述,以期为EGCG的进一步研究及开发应用提供理论依据。Epigallocatechin gallate(EGCG)is the most important monomer of polyphenols in tea extracts.Studies have shown that EGCG has anti-inflammatory,antioxidant,anti-metabolic disease and anti-tumor effects,and it also has important protective effects on cardiovascular and nervous system.Organ fibrosis is an important process in the occurrence and development of many diseases.Early diagnosis and intervention of organ fibrosis can effectively reverse the disease and improve the adverse outcome.Studies have shown that EGCG may be mediated by anti-oxidative stress,anti-inflammatory,anti-collagen production and deposition,anti-stellate cell proliferation and activation,and other ways to inhibit the occurrence and development of fibrosis.In view of EGCG may have important clinical application value in anti-organ fibrosis,this article would review the role of EGCG in organ fibrosis,in order to provide theoretical basis for further research and development of EGCG.

关 键 词：茶叶提取物 表没食子儿茶素没食子酸酯 器官纤维化 抗氧化应激 

分 类 号：R57[医药卫生—消化系统]