Research progress of the Hippo signaling pathway in renal cell carcinoma  

作　　者：Yiren Yang Xinxin Gan Wei Zhang Baohua Zhu Zhao Huangfu Xiaolei Shi Linhui Wang 

机构地区：[1]Department of Urology,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai,China [2]School of Materials Science and Engineering,University of Shanghai for Science and Technology,China

出　　处：《Asian Journal of Urology》2024年第4期511-520,共10页亚洲泌尿外科杂志（英文）

摘　　要：Objective:This review aimed to summarize the role of the Hippo signaling pathway in renal cell carcinoma (RCC), a urologic malignancy with subtle initial symptoms and high mortality rates due to metastatic RCC. The Hippo signaling pathway, which regulates tissue and organ sizes, plays a crucial role in RCC progression and metastasis. Understanding the involvement of the Hippo signaling pathway in RCC provides valuable insights for the development of targeted therapies and improved patient outcomes.Methods:In this review, we explored the impact of the Hippo signaling pathway on RCC. Through an analysis of existing literature, we examined its role in RCC progression and metastasis. Additionally, we discussed potential therapeutic strategies targeting the Hippo pathway for inhibiting RCC cell growth and invasion. We also highlighted the importance of investigating interactions between the Hippo pathway and other signaling pathways such as Wnt, transforming growth factor-beta, and PI3K/AKT, which may uncover additional therapeutic targets.Results:The Hippo signaling pathway has shown promise as a target for inhibiting RCC cell growth and invasion. Studies have demonstrated its dysregulation in RCC, with altered expression of key components such as yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ). Targeting the Hippo pathway has been associated with suppressed tumor growth and metastasis in preclinical models of RCC. Furthermore, investigating crosstalk between the Hippo pathway and other signaling pathways has revealed potential synergistic effects that could be exploited for therapeutic interventions.Conclusion:Understanding the role of the Hippo signaling pathway in RCC is of paramount importance. Elucidating its functions and molecular interactions contributes to RCC diagnosis, treatment, and the discovery of novel mechanisms. This knowledge informs the development of innovative therapeutic strategies and opens new avenues for research in RCC. Further investigations are warranted

关 键 词：The Hippo signaling pathway YAP/TAZ Renal cell carcinoma PROLIFERATION METASTASIS PROGNOSIS 

分 类 号：R737.11[医药卫生—肿瘤]