酿酒酵母高级醇代谢的转录调控研究进展  

Transcriptional regulation of higher alcohol metabolism in Saccharomyces cerevisiae

作　　者：陈璐 刘延琳[1] 秦义[1,2,3] CHEN Lu;LIU Yanlin;QIN Yi(College of Enology,Northwest A&F University,Yangling 712100,Shaanxi,China;National Forestry and Grassland Administration Engineering Research Center for Viti-viniculture,Yangling 712100,Shaanxi,China;Heyang Viti-viniculture Station,Northwest A&F University,Weinan 714000,Shaanxi,China)

机构地区：[1]西北农林科技大学葡萄酒学院,陕西杨凌712100 [2]国家林业和草原局葡萄与葡萄酒工程技术研究中心,陕西杨凌712100 [3]西北农林科技大学合阳葡萄试验示范站,陕西渭南714000

出　　处：《微生物学报》2024年第12期4669-4680,共12页Acta Microbiologica Sinica

基　　金：昌吉州科技支撑产业高质量发展专项(2022Z03);宁夏回族自治区重点研发计划(2023BCF01027);国家现代农业产业技术体系项目(CARS-29-jg-03);合阳葡萄试验示范站共建专项(2023WNXNZX-2)。

摘　　要：高级醇是酿酒酵母在葡萄酒酿造过程中产生的主要代谢副产物,其代谢受到多层次调控体系的精细调节。酿酒酵母高级醇代谢途径中的酶系及其编码基因已基本明确,但酿酒酵母高级醇代谢的转录调控机制仍不清晰。本文在总结酵母高级醇代谢途径及其代谢调控策略的基础上,重点综述了参与酵母高级醇代谢调控的转录因子Aro80p、GATA和Leu3p及其作用机制。旨在为系统理解酵母高级醇代谢转录调控机制,以及选育高级醇产量适中的酵母菌种提供理论参考。Higher alcohols,major metabolic byproducts produced by Saccharomyces cerevisiaeduring winemaking,are intricately regulated by a multilevel system.While the enzymatic machinery and their encoding genes involved in the metabolic pathways of higher alcohols in S.cerevisiae have been largely elucidated,the transcriptional regulation underlying this process remains poorly understood.This paper,building upon a summary of the metabolic pathways and regulatory strategies of higher alcohols metabolism in yeast,focuses on the transcription factors Aro80p,GATA and Leu3p implicated in the regulation of higher alcohols metabolism in yeast and their mechanisms of action.The review aims to give theoretical insights into a comprehensive understanding of the transcriptional regulation of higher alcohols metabolism in yeast and facilitate the breeding of yeast strains with moderate production of higher alcohols.

关 键 词：酿酒酵母 高级醇 转录因子 转录调控 

分 类 号：TS262.6[轻工技术与工程—发酵工程]