Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap  

作　　者：Xiao-Man Chen Shuo Zhang Shi-Qi Gao Michael Xu 

机构地区：[1]Department of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China [2]Department of Rehabilitation,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110004,Liaoning Province,China [3]International Education School,China Medical University,Shenyang 110004,Liaoning Province,China

出　　处：《World Journal of Psychiatry》2025年第1期1-6,共6页世界精神病学杂志（英文）

摘　　要：There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric disorders.This editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy incidence.The purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric comorbidities.IL-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with epilepsy.Furthermore,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric comorbidities.In summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric complications.Future resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective interventions.Furthermore,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关 键 词：EPILEPSY INTERLEUKIN-6 Neuropsychiatric comorbidities Depression Tocilizu-mab NEUROINFLAMMATION Interleukin-6 receptor blockade 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]