酵母生产虾青素的基因工程育种研究进展  

Advances in Genetic Engineering Breeding of Astaxanthin-producing Yeast

作　　者：刘静 李海军 刘玉杰 赵玉雪 郑德强 贾庆文 徐波 张英华 LIU Jing;LI Hai-jun;LIU Yu-jie;ZHAO Yu-xue;ZHENG De-qiang;JIA Qing-wen;XU Bo;ZHANG Ying-hua(Shandong Freda Pharmaceutical Group Co.,Ltd.,Jinan 250101,China;Shandong Freda Biotechnology Co.,Ltd.,Linyi 276000,China;Shandong Provincial Key Laboratory of Mucosal and Skin Drug Delivery Technology,Jinan 250101,China)

机构地区：[1]山东福瑞达医药集团有限公司,山东济南250101 [2]山东福瑞达生物科技有限公司,山东临沂276000 [3]山东省黏膜与皮肤给药技术重点实验室,山东济南250101

出　　处：《食品与药品》2024年第6期I0037-I0043,共7页Food and Drug

摘　　要：虾青素是一种酮类胡萝卜素,具有显著的生物活性和较高的经济价值,主要应用于制药、保健品、化妆品及食品和饲料行业。目前天然微生物虾青素产率低,限制了其扩大应用,因此,通过基因工程改造微生物生产虾青素的方式受到广泛关注。本文综述了近年通过基因工程育种,提高酵母中原生或异源虾青素产量的研究进展。Astaxanthin is a ketocarotenoid with significant biological activity and high economic value.It is mainly used in pharmaceuticals,health care products,cosmetics,and food and feed industries.At present,the low yield of natural microbial astaxanthin restricts its expansion of application.Therefore,the method of producing astaxanthin through genetic engineering of microorganisms has attracted extensive attention.This paper reviews the research progress of improving the yield of original or heterologous astaxanthin in yeast by genetic engineering breeding in recent years.

关 键 词：虾青素 基因工程 育种 酵母 产量 

分 类 号：Q78[生物学—分子生物学]