Application of biomechanics in tumor epigenetic research  

作　　者：Qi Wang Xiaohong Yin Yunyi Ding Hong Zhao Yichen Luo 

机构地区：[1]School of Mechanical Engineering,Zhejiang University,Hangzhou,310058,China [2]The First School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China [3]State Key Laboratory of Fluid Power&Mechatronic Systems,Zhejiang University,Hangzhou 310058,China [4]Department of Emergency Medicine,The Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China [5]Department of Breast Surgery,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine),Hangzhou 310006,China

出　　处：《Mechanobiology in Medicine》2024年第4期45-58,共14页力学生物学与医学（英文）

基　　金：supported by Science and Technology Program of Zhejiang Province(Grant No.2023C03071).

摘　　要：The field of cancer research is increasingly recognizing the complex interplay between biomechanics and tumor epigenetics.Biomechanics plays a significant role in the occurrence,development,and metastasis of cancer and may exert influence by impacting the epigenetic modifications of tumors.In this review,we investigate a spectrum of biomechanical tools,including computational models,measurement instruments,and in vitro simulations.These tools not only assist in deciphering the mechanisms behind these epigenetic changes but also provide novel methods for characterizing tumors,which are significant for diagnosis and treatment.Finally,we discuss the potential of new therapies that target the biomechanical properties of the tumor microenvironment.There is hope that by altering factors such as the stiffness of the extracellular matrix or interfering with mechano-sensing pathways,we can halt tumor progression through epigenetic mechanisms.We emphasize the necessity for multidisciplinary efforts to integrate biomechanics with tumor epigenetics more comprehensively.Such collaboration is anticipated to advance therapeutic strategies and enhance our understanding of cancer biology,signaling the dawn of a new era in cancer treatment and research.

关 键 词：TUMOR BIOMECHANICS EPIGENETIC Tumor microenvironment 

分 类 号：R73-3[医药卫生—肿瘤]