Recent advances in spatio-temporally controllable systems for management of glioma  

作　　者：Huiwen Zhang Wanqi Zhu Wei Pan Xiuyan Wan Na Li Bo Tang 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong,Institute of Molecular and Nano Science,Shandong Normal University,Jinan 250014,China [2]Laoshan Laboratory,Qingdao 266237,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第5期28-53,共26页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(22374092,and 22104074);Natural Science Foundation of Shandong Province(ZR2022YQ10);Natural Science Foundation of Shandong Province(Major Basic Research Project)(ZR2023ZD44);Project of Shandong Provincial Laboratory(SYS202207);Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province(2022KJ338).

摘　　要：Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite the great advances in conventional treatment approaches,including surgery and chemotherapy.Spatio-temporally controllable approaches to glioma are now being actively investigated due to the preponderance,including spatio-temporal adjustability,minimally invasive,repetitive properties,etc.External stimuli can be readily controlled by adjusting the site and density of stimuli to exert the cytotoxic on glioma tissue and avoid undesired injury to normal tissues.It is worth noting that the removability of external stimuli allows for on-demand treatment,which effectively reduces the occurrence of side effects.In this review,we highlight recent advancements in drug delivery systems for spatio-temporally controllable treatments of glioma,focusing on the mechanisms and design principles of sensitizers utilized in these controllable therapies.Moreover,the potential challenges regarding spatio-temporally controllable therapy for glioma are also described,aiming to provide insights into future advancements in this field and their potential clinical applications.

关 键 词：Glioma therapy Spatio-temporally controllable PHOTOTHERAPY Sonodynamic therapy RADIOTHERAPY Magnetic therapy 

分 类 号：R739.4[医药卫生—肿瘤]