短链脂肪酸介导的肠骨轴在骨代谢中的研究进展  

Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism

作　　者：张萱 杨雪 李新科 孟璐[1,2] 王加启[1,2] 郑楠[1,2] ZHANG Xuan;YANG Xue;LI Xinke;MENG Lu;WANG Jiaqi;ZHENG Nan(Key Laboratory of Quality&Safety Control for Dairy Products of China Ministry of Agriculture and Rural Affairs,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Laboratory of Quality&Safety Risk Assessment for Dairy Products of China Ministry of Agriculture and Rural Affairs(Beijing),Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,农业农村部奶及奶制品质量安全控制重点实验室,北京100193 [2]中国农业科学院北京畜牧兽医研究所,农业农村部奶产品质量安全风险评估实验室(北京),北京100193

出　　处：《食品科学》2025年第2期260-267,共8页Food Science

基　　金：“十四五”国家重点研发计划重点专项(2022YFD1600104);中国农业科学院科技创新工程项目(ASTIP-IAS12);现代农业产业技术体系建设专项(CARS36)。

摘　　要：随着全球老龄化加剧,骨质疏松症等与年龄相关的骨骼代谢疾病发病率不断上升,寻求安全有效的治疗干预方法至关重要。目前肠道微生物及其代谢产物调节骨代谢已成为研究的热点。短链脂肪酸(short-chain fatty acids,SCFAs)如乙酸、丙酸和丁酸等,能够通过肠-骨轴发挥骨形成和骨吸收的调节作用,对骨稳态调节具有一定的积极作用,并能改善炎症性骨丢失。本文综述SCFAs通过内分泌、免疫、改善营养吸收等途径调控骨代谢稳态,以期为老年代谢性骨病的预防和治疗提供科学依据。As global aging intensifies,the incidence of age-related bone metabolic disorders,such as osteoporosis,continues to climb.Seeking safe and effective therapeutic interventions is of utmost importance.The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a focal area of research.Short-chain fatty acids(SCFAs),including acetic,propionic,and butyric acids,exert regulatory effects on bone formation and resorption through the gutbone axis.Furthermore,SCFAs play positive roles in maintaining bone homeostasis and contribute to the alleviation of inflammatory bone loss.This review synthesizes the current knowledge about the mechanism by which SCFAs regulate bone metabolic homeostasis via endocrine pathways,immune modulation,and enhanced nutrient absorption,hoping to provide a scientific foundation for the prevention and treatment of metabolic bone diseases in the elderly.

关 键 词：肠-骨轴 短链脂肪酸 肠道微生物 骨代谢 骨质疏松症 

分 类 号：TS201.4[轻工技术与工程—食品科学]