香菇多糖结构与功能研究进展  

Research Progress on Structure and Function of Lentinan

作　　者：董浩然 姜宁[1] 陆欢[1] 付阳 李巧珍[1] 于海龙[1] DONG Haoran;JIANG Ning;LU Huan;FU Yang;LI Qiaozhen;YU Hailong(Key Laboratory of Edible Fungi Resources and Utilization(South),Ministry of Agriculture and Rural Affairs,National Engineering Research Center of Edible Fungi,Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,Shanghai 201403,China)

机构地区：[1]上海市农业科学院食用菌研究所,国家食用菌工程技术研究中心,农业农村部南方食用菌资源利用重点实验室,上海201403

出　　处：《生物技术进展》2024年第6期911-919,共9页Current Biotechnology

基　　金：国家现代农业产业技术体系项目(CARS-20);山东省重点研发项目(20221ZGC023);上海市农业科学院卓越团队〔沪农科卓(2022)001〕;山东省泰山产业领军人才项目(LJNY202116)。

摘　　要：香菇(Lentinula edodes)作为我国重要食用菌,具有悠久的栽培历史,如今在全球广泛应用于食品和药用领域。香菇富含生物活性多糖,其中β-葡聚糖的含量尤为丰富。自20世纪70年代以来,人们发现香菇多糖的抗癌生物活性之后,针对香菇多糖的活性研究从未停止。研究表明,香菇多糖具有多种显著的生物活性,涵盖抗氧化、抗肿瘤、抗衰老、抗炎、免疫调节、抗病毒、保肝以及降胆固醇等功效。香菇多糖的分离提纯方法、化学性质与生物活性一直备受世界各地学者的密切关注。基于前人的工作基础,全面总结了香菇多糖的最新研究进展,包括香菇多糖的分离方法及不同分离方法对其结构活性的影响、结构特征与多糖生物活性的关系以及香菇多糖在发挥生物活性时的作用机制等内容,期望为香菇多糖在医疗和功能性食品领域的进一步应用提供有价值的信息参考。Lentinula edodes,as an important edible fungus in China,has a long history of cultivation.It is now widely used in the fields of food and medicine worldwide.Lentinula edodes is rich in bioactive polysaccharides,especially β-glucan.Since the discovery of the anticancer biological activity of lentinan in the 1970 s,the research on the activity of lentinan has never stopped.Studies have shown that lentinan possesses a variety of significant biological activities,including antioxidant,anti-tumor,antiaging,anti-inflammatory,immunomodulatory,antiviral,hepatoprotective,and cholesterol-lowering effects.The isolation,purification,chemical properties,and biological activities of lentinan have always attracted close attention from scholars around the world.Based on the previous work,this article comprehensively summarized the latest research progress of lentinan,including the separation methods of lentinan and the impact of different separation methods on its structural activity,the relationship between structural characteristics and polysaccharide biological activity,and the mechanism of action of lentinan in exerting biological activity.The paper was expected to provide valuable information references for the further application of lentinan in the fields of medical treatment and functional foods.

关 键 词：香菇 香菇多糖 分离提纯 结构特征 生物活性 

分 类 号：Q539[生物学—生物化学] S646.1[农业科学—蔬菜学]