Freeze-dried jaboticaba(Myrciaria jaboticaba)peel powder,a rich source of anthocyanins and phenolic acids,mitigates inflammation-driven colorectal cancer in mice  

作　　者：Roberto de Paula do Nascimento Julia Soto Rizzato Gabriele Polezi Amanda Maria Tomazini Munhoz Moya Milena Ferreira Silva Ana Paula da Fonseca Machado Gilberto Carlos Franchi Junior Renata Galhardo Borguini Manuela Cristina Pessanha de Araújo Santiago Ana Paula Ribeiro Paiotti JoséAires Pereira Carlos Augusto Real Martinez Mario Roberto Marostica Junior 

机构地区：[1]Laboratory of Nutrition and Metabolism(LANUM),Department of Food Science and Nutrition(DECAN),School of Food Engineering(FEA),University of Campinas(UNICAMP),Campinas,SP,Brazil [2]Laboratory of Food,Nutrition,and Health,Department of Food Science and Nutrition(DECAN),School of Food Engineering(FEA),University of Campinas(UNICAMP),Campinas,SP,Brazil [3]Laboratory of Cellular and Behavioral Pharmacology,Federal University of São Paulo(UNIFESP),Diadema Campus,Diadema,SP,Brazil [4]Integrated Research Center for Onco-Hematological Childhood Diseases,School of Medical Sciences(FCM),University of Campinas(UNICAMP),Campinas,SP,Brazil [5]Brazilian Agricultural Research Corporation(EMBRAPA),Embrapa Food Technology,Rio de Janeiro,RJ,Brazil [6]Laboratory of Hepatology,Molecular Applied-Discipline of Gastroenterology,Federal University of S˜ao Paulo(UNIFESP),S˜ao Paulo Campus,S˜ao Paulo,SP,Brazil [7]Postgraduate Program in Health Sciences,S˜ao Francisco University(USF),Bragança Paulista Campus,Bragança Paulista,SP,Brazil

出　　处：《Food Bioscience》2023年第3期1060-1071,共12页食品生物科学（英文）

基　　金：financed in part by the 1.Coordenaçāo de Aperfei-çoamento de Pessoal de Nível Superior(CAPES),Brazil-Finance Code 001;Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq),Brazil-processes 140812/2019-9,403328/2016-0,301496/2019-6,117020/2019-2,and 120659/2019-0;Fundaçāo de Amparoa Pesquisa do Estado de Sāo Paulo(FAPESP),Brazil-processes 2015/50333-1,2015/13320-9,2017/23657-6,2018/11069-5,2019/03228-9,and 2020/00414-3;Red Iberoamer-icana de Alimentos Autoctonos Subutilizados-Spain(ALSUB-CYTED,118RT0543)。

摘　　要：This study aimed to characterize the peel of jaboticaba(Myrciaria jaboticaba(Vell.)O.Berg)by spectropho-tometry and chromatography,and investigate its effects on mice with inflammation-driven colorectal cancer(CRC).Freeze-dried jaboticaba peel(FDJP)showed a high antioxidant capacity in vitro,and to be mostly a source of cyanidin-3-O-glucoside,gallic acid,and ellagic acid.In the animal bioassay,FDJP added at 5%in the diet during 114 days completely abolished the formation of adenocarcinoma,which had an incidence of 75%in the non-treated group.Animals consuming FDJP showed low histology damage regarding inflammatory infiltrate,edema,and crypt distortion.FDJP significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2,and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa B.In summary,FDJP mitigated CRC,possibly by avoiding trig-gering inflammation.Such benefit may come from its rich content in anthocyanins and phenolic acids.

关 键 词：Brazil CARCINOGENESIS COLITIS Cyanidin-3-O-Glucoside Flavonoid FRUIT 

分 类 号：TS201.2[轻工技术与工程—食品科学]