Ginger essential oil(Zingiber officinale)encapsulated in nanoliposome as innovative antioxidant and antipathogenic smart sustained-release system  

作　　者：Mohammad Ekrami Mansour Babaei Morteza Fathi Sepideh Abbaszadeh Mohammad Nobakht 

机构地区：[1]Health Research Center,Life Style Institute,Baqiyatallah University of Medical Sciences,Tehran,Iran [2]Health Management Research Center,Baqiyatallah University of Medical Sciences,Tehran,Iran [3]Marine Medicine Research Center,Baqiyatallah University of Medical Sciences,Tehran,Iran

出　　处：《Food Bioscience》2023年第3期2741-2752,共12页食品生物科学（英文）

摘　　要：Ginger(Zingiber officinale)essential oil(G_(EO))was loaded into nanoliposome(NL_(P))for smart release in simulated in-vitro digestion.Optimal conditions for the fabrication of NL_(p)-G_(EO) were determined according to physical stability,size distribution and particle size.Morphological analyses(atomic force microscopy(AFM)and scan-ning electron microscopy(SEM))confirmed the results of the dynamic light scattering(DLS).Structural evalu-ation(differential Scanning Calorimetry(DSC)and Fourier-transform infrared spectroscopy(FTIR))demonstrated the interaction between G_(EO) and NL_(P).Additionally,the approximate size and loading capacity of optimized NL_(p)-G_(EO)(100 nm)was 100 nm and 66.24%.NL_(p)-G_(EO) release under oral,gastric,and intestinal conditions showed that over 90%of the nutraceutical was released after exposure to model gastrointestinal conditions.Finally,NL_(p)-G_(EO) structure showed an improved antioxidant,UV stability and reduced cytotoxicity on cell lines(human colon cancer(HT-29))and normal human umbilical vein endothelial cells(HUVEC).As an innovative smart sustained-release system in simulated in-vitro digestion,NL_(P)-G_(EO) would be a potential practical option in the food and pharmaceutical industries.

关 键 词：BIOAVAILABILITY CYTOTOXICITY GINGER Nanoliposome Stability SUSTAINED-RELEASE 

分 类 号：TS206.4[轻工技术与工程—食品科学]