Signaling pathways involved in colorectal cancer:pathogenesis and targeted therapy  

作　　者：Qing Li Shan Geng Hao Luo Wei Wang Ya-Qi Mo Qing Luo Lu Wang Guan-Bin Song Jian-Peng Sheng Bo Xu 

机构地区：[1]The Shapingba Hospital,Chongqing University,Chongqing,China [2]Chongqing Key Laboratory of Intelligent Oncology for Breast Cancer,Chongqing University Cancer Hospital and School of Medicine,Chongqing University,Chongqing,China [3]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,China [4]Central Laboratory,The Affiliated Dazu Hospital of Chongqing Medical University,Chongqing,China [5]Cancer Center,Daping Hospital,Army Medical University,Chongqing,China [6]Chongqing Municipal Health and Health Committee,Chongqing,China [7]College of Artificial Intelligence,Nanjing University of Aeronautics and Astronautics,Nanjing,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期4856-4903,共48页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(82203066,to Q.L.);the Chongqing Natural Science Foundation(2024NSCQMSX3327,to Q.L.);the National Natural Science Foundation of China(61906022,to B.X.);Chongqing University Research Fund 2021CDJXKJC004.

摘　　要：Colorectal cancer(CRC)remains one of the leading causes of cancer-related mortality worldwide.Its complexity is influenced by various signal transduction networks that govern cellular proliferation,survival,differentiation,and apoptosis.The pathogenesis of CRC is a testament to the dysregulation of these signaling cascades,which culminates in the malignant transformation of colonic epithelium.This review aims to dissect the foundational signaling mechanisms implicated in CRC,to elucidate the generalized principles underpinning neoplastic evolution and progression.We discuss the molecular hallmarks of CRC,including the genomic,epigenomic and microbial features of CRC to highlight the role of signal transduction in the orchestration of the tumorigenic process.Concurrently,we review the advent of targeted and immune therapies in CRC,assessing their impact on the current clinical landscape.The development of these therapies has been informed by a deepening understanding of oncogenic signaling,leading to the identification of key nodes within these networks that can be exploited pharmacologically.Furthermore,we explore the potential of integrating AI to enhance the precision of therapeutic targeting and patient stratification,emphasizing their role in personalized medicine.In summary,our review captures the dynamic interplay between aberrant signaling in CRC pathogenesis and the concerted efforts to counteract these changes through targeted therapeutic strategies,ultimately aiming to pave the way for improved prognosis and personalized treatment modalities in colorectal cancer.

关 键 词：PATHOGENESIS TARGETED COLORECTAL 

分 类 号：R730.5[医药卫生—肿瘤]