Iron homeostasis and ferroptosis in human diseases:mechanisms and therapeutic prospects  

作　　者：Qin Ru Yusheng Li Lin Chen Yuxiang Wu Junxia Min Fudi Wang 

机构地区：[1]Institute of Intelligent Sport and Proactive Health,Department of Health and Physical Education,Jianghan University,Wuhan,China [2]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,China [4]The First Affiliated Hospital,Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou,China [5]The Second Affiliated Hospital,School of Public Health,State Key Laboratory of Experimental Hematology,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期5015-5078,共64页信号转导与靶向治疗（英文）

基　　金：supported in part by the National Natural Science Foundation of China(31970689 to J.M.,32330047 and 31930057 to F.W.,82071970 to Y.W.and 82072506 to Y.L.);the Science Fund for Distinguished Young Scholars of Hubei Province(2023AFA109 to Y.W.);Hubei Provincial Natural Science Foundation of China(2024AFB971 to Q.R.).

摘　　要：Iron,an essential mineral in the body,is involved in numerous physiological processes,making the maintenance of iron homeostasis crucial for overall health.Both iron overload and deficiency can cause various disorders and human diseases.Ferroptosis,a form of cell death dependent on iron,is characterized by the extensive peroxidation of lipids.Unlike other kinds of classical unprogrammed cell death,ferroptosis is primarily linked to disruptions in iron metabolism,lipid peroxidation,and antioxidant system imbalance.Ferroptosis is regulated through transcription,translation,and post-translational modifications,which affect cellular sensitivity to ferroptosis.Over the past decade or so,numerous diseases have been linked to ferroptosis as part of their etiology,including cancers,metabolic disorders,autoimmune diseases,central nervous system diseases,cardiovascular diseases,and musculoskeletal diseases.Ferroptosis-related proteins have become attractive targets for many major human diseases that are currently incurable,and some ferroptosis regulators have shown therapeutic effects in clinical trials although further validation of their clinical potential is needed.Therefore,in-depth analysis of ferroptosis and its potential molecular mechanisms in human diseases may offer additional strategies for clinical prevention and treatment.In this review,we discuss the physiological significance of iron homeostasis in the body,the potential contribution of ferroptosis to the etiology and development of human diseases,along with the evidence supporting targeting ferroptosis as a therapeutic approach.Importantly,we evaluate recent potential therapeutic targets and promising interventions,providing guidance for future targeted treatment therapies against human diseases.

关 键 词：DISEASES HOMEOSTASIS THERAPEUTIC 

分 类 号：R45[医药卫生—治疗学]