南方食管癌高、低发区人群总N-亚硝基化合物接触水平  

Exposure level of total N-nitroso compounds in residents of high-and low-risk areas for esophageal cancer in southern

作　　者：林昆[1] 沈文英[1] 吴永宁[2] 陆士新[3] 

机构地区：[1]广东省汕头市汕头大学医学院,515031 [2]中国预防医学科学院营养与食品卫生研究所 [3]中国医学科学院肿瘤研究所

出　　处：《中华预防医学杂志》2002年第6期386-389,共4页Chinese Journal of Preventive Medicine

基　　金：广东省高等教育厅科研基金资助课题 (B19980 17);广东省卫生厅科研基金资助课题 (A19993 78)

摘　　要：目的　评价南方食管癌高发区和低发区人群总N 亚硝基化合物 (TNOC)的接触水平。方法　在食管癌高发区南澳县和低发区陆丰县各随机选择 12 0名 35～ 6 4岁男性 ,采用双份饭法收集2 4h膳食和 12h尿液 ,测定TNOC、非挥发性亚硝胺和挥发性亚硝胺。结果　高发区膳食TNOC检出率(95 % )、膳食TNOC日摄入量 [(4 2 5± 0 84 ) μmol/d]和尿 12h排出量 [(1 76± 0 2 3)ng/ 12h]、膳食挥发性亚硝胺日摄入量 [(2 6 6± 31 2 ) μg/d]均高于低发区。食管癌死亡率分别与膳食TNOC日摄入量和尿TNOC排泄量呈等级正相关关系。尿非挥发性亚硝胺排泄量两地无差异。Objective To assess the exposure level of total N nitroso compounds (TNOCs) in the residents of high and low risk areas for esophageal cancer in southern China Methods Samples of duplicate plate diets and 12 hr overnight urine were collected from 120 male adults in each of the 2 areas, a high risk area (Nanao county) and a low risk area (Lufeng county) for esophageal cancer The 240 male healthy subjects (35 64 years old) were selected by a 3 stage random cluster sampling procedure Levels of TNOC, N nitrosamino acids (NAAs) and volatile N nitroso compounds (VNOC) in the samples were measured by Thermo Energy Analyzer Results The detectable rate (95%) of diet TNOC, daily dietary TNOC intake (4 25±0 84) μmol/day,12 hr urinary TNOC excretion levels (1 76±0 23 ng/12h) and daily dietary intake of VNOC (266±31 2 μg/day) in the high risk area were all significantly higher than those of the low risk area Oesophageal cancer mortality rates were positively and significantly associated with daily dietary TNOC intake and 12 hr urinary TNOC excretion Urinary NAAs excretion levels were not different in the two areas Conclusion The results suggest that TNOCs may be implicated in the etiology of esophageal cancer in southern China

关 键 词：食癌 N-亚硝基化合物 接触水平 

分 类 号：R735.1[医药卫生—肿瘤]