Advances in gastrointestinal vascular bleeding disorders:Successful sirolimus treatment in colonic angioectasia  

作　　者：Qi Sun Xiao-Ying Wang Dong-Hao Li Bai-Rong Li Xin-Zhuo Tu Zhi-Meng Jiang Shou-Bin Ning Tao Sun 

机构地区：[1]Department of Gastroenterology,Air Force Medical Center,Beijing 100142,China [2]College of Life Science,Northwest University,Xi’an 710069,Shaanxi Province,China [3]Department of Pathology,Air Force Medical Center,Beijing 100142,China

出　　处：《World Journal of Gastroenterology》2025年第4期123-136,共14页世界胃肠病学杂志(英文)

基　　金：Air Force Medical Center Youth Talent Program Project,No.22YXQN034;Capital Health Development Research Special Project,No.2020-4-5123;Beijing Haidian District Health and Wellness Development Scientific Research Cultivation Program,No.HP2021-03-80803.

摘　　要：BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses.Despite advancements in diagnostic and therapeutic techniques,optimal mana-gement strategies remain elusive,necessitating further research.AIM To assess research trends and clinical advancements in GI vascular bleeding disorders,highlighting key themes and therapeutic progress.METHODS A bibliometric analysis was conducted using the Web of Science Core Collection database,reviewing publications from 2000 to 2024 to identify trends,highfrequency keywords,and key contributions from leading research institutions.In addition,a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous treatments.RESULTS The analysis reviewed 470 scholarly articles from 203 countries,involving 2817 authors across 1502 institutions.The United States led in publication contributions,with strong collaborations with countries like China,England,and Germany.A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies,particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as “angiodysplasia”,“colon”, and “management” were identified, indicating key research themes. The study also noted a growinginterest in drug therapies, as evidenced by the increasing prominence of keywords like “thalidomide” since 2018.CONCLUSIONThis study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological managementin GI vascular bleeding disorders to improve patient outcomes.

关 键 词：Gastrointestinal bleeding Vascular anomalies Angioectasia PHARMACOLOGICAL SIROLIMUS 

分 类 号：R573.4[医药卫生—消化系统]