茶多酚基于活性氧-线粒体途径发挥心血管保护作用的研究进展  

Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols

作　　者：邓婷婷 皮锦蝉 彭小平[3] 姚于飞 李义全 李文娟[1,3] DENG Tingting;PI Jinchan;PENG Xiaoping;YAO Yufei;LI Yiquan;LI Wenjuan(State Key Laboratory of Food Science and Resources,Nanchang University,Nanchang 330047,China;College of Future Technology,Nanchang University,Nanchang 330031,China;First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Affiliated Hospital of Jiangxi Traditional Chinese Medicine University,Nanchang 330006,China;Jiangxi Taiyang Hong Tea Industry Co.,Ltd.,Jiujiang 332300,China)

机构地区：[1]南昌大学食品科学与资源挖掘全国重点实验室,江西南昌330047 [2]南昌大学未来科技学院,江西南昌330031 [3]南昌大学第一附属医院,江西南昌330006 [4]江西中医药大学附属医院,江西南昌330006 [5]江西省太阳红茶业有限公司,江西九江332300

出　　处：《食品工业科技》2025年第4期434-442,共9页Science and Technology of Food Industry

基　　金：江西省中医药管理局项目(2023B1301);南昌大学江西省财政科技专项“包干制”试点示范项目(ZBG20230418013);江西省“三区人才”项目(9202-0210208651)。

摘　　要：心血管疾病是全球首要致死病因,其中活性氧(reactive oxygen species,ROS)失衡和线粒体功能障碍是导致其发生的重要机制。线粒体是ROS产生的主要场所,也是ROS攻击的靶点。大量研究证实,茶多酚能够调控ROS生成和保护线粒体结构与功能,对心血管具有显著的保护作用。因此,本文在介绍ROS的来源及其危害的基础上,概括了ROS-线粒体与心血管疾病发生和发展的内在联系以及茶多酚对ROS的清除作用,并重点对近年来茶多酚通过ROS-线粒体途径对心血管保护作用的研究进展展开综述。从ROS-线粒体视角阐明了茶多酚主要通过调控线粒体融合与分裂蛋白的表达、降低线粒体膜通透性转换孔的开放程度、维持细胞钙稳态、减轻线粒体DNA损伤以及调控线粒体凋亡的信号转导以改善心血管疾病,并进一步对茶多酚的应用前景进行展望,旨在为相关领域的研究和应用提供参考。Reactive oxygen species(ROS)imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide.Mitochondrion is the main ROS production,which is also the vulnerable target for ROS attack.Compelling evidence has been provided that tea polyphenols could regulate ROS generation and protect mitochondrial structure and function,contributing to its beneficial health effects on cardiovascular protection.Hence,the article introduces the sources and detrimental effects of ROS,then the intrinsic connections between ROS,mitochondria,and the development of cardiovascular diseases,as well as the ROS-scavenging effects of tea polyphenols are summarized.From the perspective of ROS-mitochondrial pathway,the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins,reducing the opening of mitochondrial membrane permeability transition pore,maintaining cellular calcium homeostasis,mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways.Correspondingly,the potential applications of tea polyphenols are discussed,aiming to provide valuable insights for research and application in related fields.

关 键 词：活性氧(ROS) 线粒体 心血管疾病 茶多酚 信号转导机制 

分 类 号：TS201.4[轻工技术与工程—食品科学]