Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson’s Disease  

作　　者：Meng-Zhu Pang Han-Xing Li Xue-Qin Dai Xiao-Bo Wang Jun-Yi Liu Yun Shen Xing Xu Zhao-Min Zhong Han Wang Chun-Feng Liu Fen Wang 

机构地区：[1]Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,215004,China [2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience,Soochow University,Suzhou,215123,China [3]Department of Neurology,The Fourth Affiliated Hospital of Soochow University,Suzhou,215000,China [4]Center for Circadian Clocks,Soochow University,Suzhou,215123,China [5]School of Biology&Basic Medical Sciences,Medical College,Soochow University,Suzhou,215123,China [6]Department of Neurology,Xiongan Xuanwu Hospital,Xiongan,071700,China

出　　处：《Neuroscience Bulletin》2024年第12期1901-1914,共14页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82071420,82471269);Science and Technology Innovation Project of Xiongan New Area(2023XAGG0073);Jiangsu Provincial Medical Key Discipline(ZDXK202217);Suzhou Technology Development Program(SLJ2021010);Suzhou Key Laboratory(SZS2023015).

摘　　要：Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease(PD).Melatonin has the potential to improve sleep-wake disorder,but its mechanism of action is still unclear.Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when melatonin receptor 1 was present.Thus,we explored the underlying mechanisms by applying a rotenone model.After the PD zebrafish model was induced by 10 nmol/L rotenone,the motor and sleep-wake behavior were assessed.In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes.In the PD model,we found abnormal lipid metabolism,which was reversed by melatonin.This may be one of the main pathways for improving PD sleep-wake disorder.

关 键 词：ZEBRAFISH MELATONIN Melatonin receptor 1 Parkinson’s disease Sleep-wake disorder Lipid metabolism 

分 类 号：R742.5[医药卫生—神经病学与精神病学]