The relation of synaptic biomarkers with Aβ,tau,glial activation,and neurodegeneration in Alzheimer’s disease  

作　　者：Yi-Ting Wang Nicholas J.Ashton Stijn Servaes Johanna Nilsson Marcel S.Woo Tharick A.Pascoal Cécile Tissot Nesrine Rahmouni Joseph Therriault Firoza Lussier Mira Chamoun Serge Gauthier Ann Brinkmalm Henrik Zetterberg Kaj Blennow Pedro Rosa-Neto Andréa L.Benedet 

机构地区：[1]Translational Neuroimaging Laboratory,McGill Centre for Studies in Aging,McGill University,Montreal,QC,Canada [2]Department of Psychiatry and Neurochemistry,Institute of Neuroscience&Physiology,the Sahlgrenska Academy at the University of Gothenburg,Mölndal,Sweden [3]Centre for Age-Related Medicine,Stavanger University Hospital,Stavanger,Norway [4]King’s College London,Institute of Psychiatry,Psychology and Neuroscience,Maurice Wohl Institute Clinical Neuroscience Institute,London,UK [5]NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation,London,UK [6]Department of Neurology,University Medical Center Hamburg-Eppendorf,Hamburg,Germany [7]Institute of Neuroimmunology and Multiple Sclerosis(INIMS),University Medical Center Hamburg-Eppendorf,Hamburg,Germany [8]Department of Psychiatry,University of Pittsburgh,Pittsburgh,PA,USA [9]Department of Neurology,University of Pittsburgh,Pittsburgh,PA,USA [10]Alzheimer’s Disease Research Unit,The McGill University Research Centre for Studies in Aging,Montreal,McGill University,Montreal,QC,Canada [11]Clinical Neurochemistry Laboratory,Sahlgrenska University Hospital,Mölndal,Sweden [12]Department of Neurodegenerative Disease,UCL Institute of Neurology,Queen Square,London,UK [13]UK Dementia Research Institute at UCL,London,UK [14]Hong Kong Center for Neurodegenerative Diseases,Clear Water Bay,Hong Kong,China [15]Wisconsin Alzheimer’s Disease Research Center,University of Wisconsin School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI 53792,USA [16]Montreal Neurological Institute,Montreal,QC,Canada [17]Department of Neurology and Neurosurgery,McGill University,Montreal,QC,Canada

出　　处：《Translational Neurodegeneration》2024年第1期736-740,共5页转化神经变性病(英文)

基　　金：supported by the Canadian Institutes of Health Research(CIHR)[MOP-11–51-31,RFN 152985,159815,162303];Canadian Consortium of Neurodegeneration and Aging(CCNA;MOP-11–51-31-team 1);Weston Brain Institute,the Alzheimer’s Association[NIRG-12–92090,NIRP-12–259245];Brain Canada Foundation(CFI Project 34874,33397);the Fonds de Recherche du Québec–Santé(FRQS;Chercheur Boursier,2020-VICO-279314)。

摘　　要：Main text Synaptic degeneration is a prominent feature of vari-ous neurodegenerative diseases and represents an early pathogenic event in Alzheimer’s disease(AD)[1,2].Multiple synapse-specific proteins involved in distinct synaptic pathways can be measured in the cerebrospi-nal fluid(CSF)and have been implicated as promising biomarkers of synaptic degeneration.Among them,the most extensively studied ones include the presynaptic proteins synaptosomal-associated protein-25(SNAP25),growth-associated protein-43(GAP43)and synaptotag-min-1(SYT1)and postsynaptic protein neurogranin(NRGN)[3,4].

关 键 词：GAP43 ALZHEIMER TAU AΒ 

分 类 号：R74[医药卫生—神经病学与精神病学]