Periodontitis impacts on thrombotic diseases:from clinical aspect to future therapeutic approaches  

作　　者：Jinting Ge Xuanzhi Zhu Chengxin Weng Ding Yuan Jichun Zhao Lei Zhao Tiehao Wang Yafei Wu 

机构地区：[1]Division of Vascular Surgery,Department of General Surgery,West China Hospital,Sichuan University,Chengdu,China [2]State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,China [3]Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China

出　　处：《International Journal of Oral Science》2024年第4期615-629,共15页国际口腔科学杂志(英文版)

基　　金：supported by the National Natural Science Foundation of China grant 82170970(YW),81970944(LZ),82300452(CW);Sichuan Science and Technology Program 2023NSFSC0553(LZ),2019JDRC0104(JG),2022YFS0359,2024YFFK0238(TW),2022YFS0187(DY),24QYCX0412(JZ),2024YFFK0239(JG),2024YFFK0237(CW);Post-Doctor Research Project of West China Hospital;Sichuan University2023HXBH108(JG)。

摘　　要：Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance.Uncontrolled periodontal infections are the leading cause of tooth loss in adults.Thrombotic diseases can lead to partial or complete obstruction of blood flow in the circulatory system,manifesting as organ or tissue ischemia and necrosis in patients with arterial thrombosis,and local edema,pain and circulatory instability in patients with venous thrombosis,which may lead to mortality or fatality in severe case.Recent studies found that periodontitis might enhance thrombosis through bacterial transmission or systemic inflammation by affecting platelet-immune cell interactions,as well as the coagulation,and periodontal therapy could have a prophylactic effect on patients with thrombotic diseases.In this review,we summarized clinical findings on the association between periodontitis and thrombotic diseases and discussed several novel prothrombotic periodontitis-related agents,and presented a perspective to emphasize the necessity of oral health management for people at high risk of thrombosis.

关 键 词：THROMBOTIC DISEASES CLINICAL 

分 类 号：R781.42[医药卫生—口腔医学] R543[医药卫生—临床医学]