Impact of milk and dairy consumption on the development and progression of breast cancer  

作　　者：Kakoli Patnaik Nitin Sharma Deepa Thadani 

机构地区：[1]Department of Biochemistry,JLN Medical College,Ajmer 305001,Rajasthan,India

出　　处：《Journal of Nutritional Oncology》2024年第4期112-118,共7页肿瘤营养学杂志(英文)

摘　　要：Recent studies have shown a link between the consumption of bovine milk and human breast cancer,apparently by agonizing the estrogen receptor(ER),which results in the proliferation of the breast tissues,leading to formation of a tumor.Bovine milk may also promote tumor formation via insulin-like growth factor-1(IGF-1)signaling.In addition,numerous potentially carcinogenic compounds have been found in bovinemilk,including exosomal microRNAs(miR-148a-3p,miR-21-5p),aflatoxin M1,bisphenol A,pesticides,andmicroand nanoplastics.Subjects with specific geneticmutations(e.g.,BRCA1 loss-of-function)and polymorphisms(e.g.,FTO and IGF-1 upregulation)that enhance IGF-1/mTORC1 signalingmight be especially susceptible to ER+breast cancer promoted by the consumption of bovine dairy products.However,in the previous large-scale meta-analyses,data about the milk processing methods,such as pasteurization and ultra-high temperature treatment,are lacking,thus limiting the accuracy of risk assessments.Clearer and more convincing evidence,detailed milk processing information,and data regarding the timing of exposure(consumption)are required because the current evidence suggests that the dietary recommendations regarding milk and dairy consumption may need to be reevaluated.

关 键 词：Breast cancer Bovine milk consumption ESTROGENS Fat mass and obesity associated gene INSULIN 

分 类 号：R73[医药卫生—肿瘤]