Krill oil attenuates obesity-induced skeletal muscle atrophy in mice  

作　　者：Mengqing Zhou Yuhong Yang Yan Zheng Zijian Wu Chen Chen Qijian Liang Yu Yang Hao Wu Xin Guo Lei Du 

机构地区：[1]Department of Nutrition and Food Hygiene,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China [2]Research Center of Translational Medicine,Jinan Central Hospital,Shandong University,Jinan 250013,China [3]School of Food Science and Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China

出　　处：《Food Science and Human Wellness》2025年第1期250-261,共12页食品科学与人类健康(英文)

基　　金：supported by the National Natural Science Foundation of China(82003447,32202023);the Natural Science Foundation of Shandong Province(ZR2021QC177);the Young Scholars Program of Shandong University(2018WLJH33,2018WLJH34)。

摘　　要：Obesity is associated with skeletal muscle mass loss and physical dysfunction.Krill oil(KO)has been shown to be beneficial in human health.However,the effect of KO on obesity-induced skeletal muscle atrophy is still unclear.In this study,the male C57BL/6J mice were fed a high-fat diet(HFD)for 12 weeks to induce obesity,and then were intragastric administration with 400 mg/kg bw KO for an additional 6 weeks.The results showed that KO treatment reduced body weight,fat accumulation and serum pro-inflammatory cytokines in HFD-induced obese mice.Importantly,KO treatment attenuated skeletal muscle atrophy in HFD-fed mice,as evidenced by preserving skeletal muscle mass,average myofiber cross-sectional area and grip strength.KO administration also mitigated obesity-induced ectopic lipid deposition and inflammatory response in skeletal muscle.Additionally,KO treatment inhibited the transcriptional activities of nuclear factor-κB(NF-κB)p65 and forkhead box O 3a(FoxO3a),and then down-regulated muscle atrophy F-box(MAFbx)and muscle-specific RING finger protein 1(MuRF1)protein levels in skeletal muscle from HFD-fed mice.KO administration also improved obesity-induced impaired muscle protein synthesis via activating PI3K/Akt pathway.Furthermore,KO treatment enhanced muscle mitochondrial biogenesis in HFD-induced obese mice via activating PGC-1αpathway.Collectively,KO might be developed as a potential nutritional supplement for the prevention and treatment of obesity-induced skeletal muscle atrophy.

关 键 词：OBESITY Skeletal muscle atrophy INFLAMMATION Protein turnover Mitochondrial biogenesis 

分 类 号：R151.41[医药卫生—营养与食品卫生学]