BCAR3 and BCAR3-related competing endogenous RNA expression in hepatocellular carcinoma and their prognostic value  

作　　者：Hui-Qin Shi Shu Huang Xin-Yue Ma Zhen-Ju Tan Rui Luo Bei Luo Wei Zhang Lei Shi Xiao-Lin Zhong Mu-Han Lü Xia Chen Xiao-Wei Tang 

机构地区：[1]Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [2]Department of Gastroenterology,The People’s Hospital of Lianshui,Huaian 223499,Jiangsu Province,China [3]Department of Gastroenterology,Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical University,Huaian 223499,Jiangsu Province,China [4]Department of Gastroenterology,Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第7期3082-3096,共15页世界胃肠肿瘤学杂志(英文)

摘　　要：BACKGROUND Hepatocellular carcinoma(HCC)is a malignant tumor that has a high incidence and mortality worldwide.Despite extensive studies,the detailed molecular mechanism of HCC development remains unclear.Studies have shown that the occurrence and development of HCC are closely related to abnormal gene expression.BCAR3 has been shown to be overexpressed in a variety of malignant tumors.However,the role of BCAR3 in HCC remains unclear.AIM To investigate the expression of BCAR3 and BCAR3-related competing endogenous RNAs(ceRNAs)in HCC and their clinical significance,in order to provide new ideas for the diagnosis and treatment of HCC.METHODS The data of HCC were obtained from the Cancer Genome Atlas database and The Genotype Tissue Expression,including transcriptome data and clinical information.Multiple common databases,including UALCAN,Timer 2.0,cBioPortal,LinkedOmics,starBase,Gene Ontology and Kyoto Encyclopedia of Genes and Genomes,were used to analyse the expression of BCAR3,prognostic value,genetic alteration,co-expressed genes,differentially expressed genes,BCAR3 gene-related ceRNAs and functional enrichment analysis in HCC patients.Kaplan-Meier analysis,univariate and multivariate Cox regression analysis were used to analyze survival prognosis and the Spearman test was used to measure correlations between BCAR3 and immune functions.And R language package was used to analyze the correlation between BCAR3 and immune invasion of HCC.RESULTS Our study indicated that BCAR3 was differentially expressed in various tumor tissues.The over-expression of BCAR3 gene was an unfavorable prognostic indicator for HCC patients,and associated with unfavorable cytogenetic risk and gene mutations.Moreover,most immune cells were positively correlated with BCAR3(P<0.05).According to the results of functional enrichment analysis,BCAR3 was involved in the positive regulation of epidermal growth factor receptor signaling pathway and ERBB signaling pathway,and was related to DNA replication and GTPase regulator activity.Finally,our

关 键 词：Hepatocellular carcinoma Breast cancer anti-estrogen-resistant protein 3 BIOINFORMATICS Prognosis IMMUNOASSAY 

分 类 号：R735.7[医药卫生—肿瘤]