Impact of immunosuppressants on tumor pulmonary metastasis:new insight into transplantation for hepatocellular carcinoma  

作　　者：Jinyan Chen Huigang Li Jianyong Zhuo Zuyuan Lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi Lin Renyi Su Yiyang Sun Rongsen Wang Jiancai Sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu 

机构地区：[1]Zhejiang University School of Medicine,Hangzhou 310058,China [2]Department of Hepatobiliary and Pancreatic Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China [3]School of Basic Medical Sciences and Forensic Medicine,Hangzhou Medical College,Hangzhou 310053,China [4]The Fourth School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310063,China [5]Department of Hepatobiliary and Pancreatic Surgery,Shulan(Hangzhou)Hospital,Hangzhou 310022,China [6]Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),School of Clinical Medicine,Hangzhou Medical College,Hangzhou 310014,China [7]Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China

出　　处：《Cancer Biology & Medicine》2024年第11期1033-1049,共17页癌症生物学与医学(英文版)

基　　金：supported by the Major Research Plan of the National Natural Science Foundation of China(Grant No.92159202);the Key Research&Development Plan of Zhejiang Province(Grant No.2024C03051);the National Key Research and Development Program of China(Grant No.2021YFA1100500);the National Natural Science Foundation of China(Grant No.82303387);Natural Science Foundation of Zhejiang Province(Grant No.LQ23H160048)。

摘　　要：Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).In addition to the common mechanisms underlying tumor metastasis,another inevitable factor is that the application of immunosuppressive agents,including calcineurin inhibitors(CNIs)and rapamycin inhibitors(mTORis),after transplantation could influence tumor recurrence and metastasis.In recent years,several studies have reported that mTORis,unlike CNIs,have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment.Therefore,we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs.This revelation has provided profound insights into transplant oncology,leading to a renewed understanding of the use of immunosuppressants after LT for HCC.

关 键 词：METASTASIS HEPATOCELLULAR ORGANS 

分 类 号：R735.7[医药卫生—肿瘤]