Low CXCR6 expression drives extracellular matrix remodeling and enhances cell proliferation in OSCC  

作　　者：Yang Xun Hua Yang Yilong Ai Honglin Li Hua You Fang Liu 

机构地区：[1]Department of Basic Medicine and Biomedical Engineering,School of Medicine,Foshan University,Foshan,Guangdong 528000,China [2]Foshan Stomatological Hospital,Foshan,Guangdong 528000,China [3]Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology,Department of Pediatric Hematology and Oncology,Children's Hospital of Chongqing Medical University,Chongqing 401122,China [4]Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,Children's Hospital of Chongqing Medical University,Chongqing 401122,China [5]Centre for Translational Stem Cell Biology,Hong Kong 999077,China

出　　处：《Genes & Diseases》2025年第1期5-8,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation ofChina(No.82203213,82203844,81911530169);Innovation Technology Commission Funding(Health@lnnoHK)in Hong Kong,China,Basic and Applied Basic Research Project of Guangdong Province,China(No.2020A1515111201,2019A1515110495);University Special Innovative Research Program of Department of Education of Guangdong Province,China(No.2020KQNCX073).

摘　　要：Oral cancer,primarily oral squamous cell carcinoma(OscC),is one of the most common cancer types worldwide.The incidence of oscC continues to rise,with approximately 377,713 new cases and 177,757 deaths reported worldwide by 2020.1 Despite advancements in diagnosis and treatment,the 5-year survival rate for OscC patients has remained at 60%-67%over the last two decades(SEER database:https://seer.cancer.gov/).This consistent rise in morbidity and lack of survival improvement have made OscC a public concern.

关 键 词：diagnosis CANCER REMODELING 

分 类 号：R739.85[医药卫生—肿瘤]