Research Progress on the Mechanism of GSDMDInduced Pyroptosis in Macrophages  

作　　者：Zhaoru Wu Chengxin Lv Feixiang Huang Jiedan Liao 

机构地区：[1]College of Animal Science and Technology,Foshan University,Foshan 528225,Guangdong Province,China [2]Henan Animal Health Supervision Institute,Zhengzhou 450000,Henan Province,China

出　　处：《Journal of Clinical and Nursing Research》2025年第2期79-84,共6页临床护理研究(英文)

基　　金：Foshan High-Level Talent and Lingnan Scholar Research Initiation Project(Project No.:CGZ07001);Foshan Science and Technology Innovation Project(Project No.:2420001004253);Foshan Self-Funded Science and Technology Innovation Project(Project No.:2420001004253)。

摘　　要：Pyroptosis is a form of programmed cell death.Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage,circulatory failure,and even death.Gasdermin D(GSDMD)is the primary executor of pyroptosis in macrophages.Upon cleavage,the N-terminal domain of GSDMD(GSDMD-N)is activated and oligomerizes to form pore-like structures in the plasma membrane,triggering pyroptosis and resulting in the release of pro-inflammatory cytokines such as interleukin-1β(IL-1β).As a key executioner molecule of pyroptosis,Gasdermin D plays a crucial role in pathogen-induced pyroptosis in macrophages.With in-depth research on the function and regulatory mechanisms of GSDMD,its role in pathogen-induced macrophage pyroptosis has gradually been revealed.This article elaborates on the mechanism of GSDMD in pathogen-induced macrophage pyroptosis,providing insights for exploring pyroptosis in the prevention and control of bacterial diseases,and identifying new therapeutic targets for bacterial infections.

关 键 词：GSDMD PYROPTOSIS MACROPHAGES 

分 类 号：R36[医药卫生—病理学]