Elucidating the synergistic roles of CD4^(+)T and dendritic cells in antitumor immunity  

作　　者：Xiubao Ren 

机构地区：[1]Department of Immunology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin 300060,China [2]Department of Biotherapy,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin 300060,China [3]Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Key Laboratory of Cancer Immunology and Biotherapy,Tianjin 300060,China

出　　处：《Cancer Biology & Medicine》2025年第1期1-5,共5页癌症生物学与医学(英文版)

摘　　要：A recent publication by Espinosa-Carrasco et al.1has illuminated the critical roles of intratumoral immune triads-a unique cluster of CD4^(+)T cells,CD8^(+)T cells,and dendritic cells(DCs)-in mediating effective antitumor responses.These triads ensure that CD8^(+)T cells receive the necessary help from CD4^(+)T cells,mediated via the same DC,to effectively targeting and destroying cancer cells.The article’s novel insight suggests a shift in focus from increasing the number of immune cells to optimizing their interactions within the tumor microenvironment.This groundbreaking study not only underscores the critical roles of CD4^(+)T cells and DCs,but also highlights the intricate interplay among immune cell subsets within the tumor microenvironment.

关 键 词：IMMUNITY TUMOR 

分 类 号：R730.51[医药卫生—肿瘤]