Supplemental n-3 polyunsaturated fatty acids:Clinical implications and best practices for adult patients with cancer  

作　　者：Jing-Shu Yang Hai-Yan Wang Xin-Ting Zhang Song-Yu Wang Xiao-Tian Duan Quan-Tong Zhao Ran Wang Yao Wang Hong-Shi Cao 

机构地区：[1]Department of Oncology,The First Bethune Hospital of Jilin University,Changchun 130021,Jilin,China [2]Department of Nursing,The First Bethune Hospital of Jilin University,Changchun 130021,Jilin,China [3]Department of Neurotrauma Surgery,The First Bethune Hospital of Jilin University,Changchun 130021,Jilin,China

出　　处：《Journal of Nutritional Oncology》2025年第1期1-7,共7页肿瘤营养学杂志(英文)

摘　　要：Background:The purpose of this report is to summarize the evidence supporting supplementation of n-3 polyunsaturated fatty acids(n-3 PUFAs)in adult cancer patients,and to offer a better understanding of the appropriate use of n-3 PUFAs in the clinical setting.Methods:Numerous databases were searched for guidelines,clinical decision-making documents,systematic reviews,expert consensus statements,and best evidence summaries about the use of n-3 PUFAs in cancer patients from the inception of the database to December 31,2023.Evidence grading and recommendation rating were conducted.The data extracted included the timing of supplementation,symptom management,disease prevention,cost-effectiveness,route of administration,application scenarios,dosage,and safety.Results:The collected data show that n-3 PUFAs are safe for patients receiving chemotherapy who are at risk of malnutrition and cachexia.Moreover,n-3 PUFA supplementation can alleviate the adverse symptoms associated with chemotherapy,extend survival,and improve the quality of life of patients with cancer.Conclusions:The administration of supplementary n-3 PUFAs should be considered based on the patient’s disease stage,treatment plan,nutritional status,and tolerance,as well as the dosage,route and application scenarios.Promoting the clinical use of n-3 PUFAs may improve the outcomes for patients with cancer.

关 键 词：TUMOR n-3 polyunsaturated fatty acids Nutritional supplementation IMMUNITY 

分 类 号：R730[医药卫生—肿瘤]