Discovery of a novel viroid-like circular RNA in colorectal cancer  

作　　者：Meini Wu Wenliang Li Ningzhu Hu Changning Liu Jianfang Li Yanhan Li Ning Xu Jiandong Shi Jing Sun Jing Li Yunzhang Hu 

机构地区：[1]Institute of Medical Biology,Chinese Academy of Medical Sciences&Peking Union Medical College,Kunming,Yunnan,P.R.China [2]Department of Colorectal Surgery,Yunnan Cancer Hospital&The Third Affiliated Hospital of Kunming Medical University&Yunnan Cancer Center,Kunming,Yunnan,P.R.China [3]CAS Key Laboratory of Tropical Plant Resources and Sustainable Use,Yunnan Key Laboratory of Crop Wild Relatives Omics,Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences,Kunming,Yunnan,P.R.China [4]Department of Oncology,First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R.China

出　　处：《Cancer Communications》2025年第1期46-50,共5页癌症通讯(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.31500748);the CAMS Innovation Fund for Medical Sciences(No.2017-I2M-3-022).

摘　　要：Viroids,the smallest known infectious agents,were initially discovered in plants[1],and have caused significant agricultural diseases[2–4].Recently,viroids have been identified in fungi[5–7]and bacteria[8],but none have been identified in animals.To date,no studies have explored the presence of viroids in colorectal cancer(CRC).We employed a reference-free computational method to identify a novel viroid-like circular RNA(circRNA)in CRC patients.Our study suggests that a broader class of viroids may exist in living systems.

关 键 词：COLORECTAL CANCER CIRCULAR 

分 类 号：R73[医药卫生—肿瘤]