食药用菌中天然活性成分调控尿酸代谢机制研究进展  

Research Progress on the Mechanisms by Which Natural Active Ingredients from Edible and Medicinal Fungi Regulate Uric Acid Metabolism

作　　者：文静 殷朝敏[2,3] 范秀芝 史德芳[2,3] 姚芬 于巍[2,3] 高虹 WEN Jing;YIN Chaomin;FAN Xiuzhi;SHI Defang;YAO Fen;YU Wei;GAO Hong(School of Life and Health Sciences,Hubei University of Technology,Wuhan 430068,China;National Research and Development Center for Edible Fungi Processing,Institute of Agro-products Processing and Nuclear-Agricultural Technology,Hubei Academy of Agricultural Sciences,Wuhan 430064,China;Key Laboratory of Cold Chain Logistics Technology for Agro-product,Ministry of Agriculture and Rural Affairs,Wuhan 430064,China;Hubei Xianggu Mushroom Industrial Technology Research Institute,Suizhou 441309,China)

机构地区：[1]湖北工业大学生命科学与健康工程学院,湖北武汉430068 [2]湖北省农业科学院农产品加工与核农技术研究所,国家食用菌加工技术研发分中心,湖北武汉430064 [3]农业农村部农产品冷链物流技术重点实验室,湖北武汉430064 [4]湖北省香菇产业技术研究院,湖北随州441309

出　　处：《食品科学》2025年第7期328-336,共9页Food Science

基　　金：国家自然科学基金面上项目(32072229);国家自然科学基金青年科学基金项目(31801921);“十四五”国家重点研发计划重点专项(2024YFD2100801,2024YFD2100802);湖北省技术研发重大项目(2024BBB028,2023BEB022);湖北省食用菌产业体系加工岗项目(2023HBSTX4-09)。

摘　　要：高尿酸血症和痛风是由于人体中尿酸含量过高而导致的代谢性疾病。随着人们生活质量的不断提高,高尿酸血症和痛风的患病率逐渐增加,且患者呈年轻化趋势,对人体健康产生了巨大的危害。近年研究发现,食药用菌中一些天然活性成分在改善高尿酸血症方面具有显著效果。因此,本文结合国内外最新研究,以尿酸代谢过程、高尿酸血症和痛风的发病机制为基础,对食药用菌中主要活性成分调控尿酸代谢机制进行综述,以期为食药用菌中活性成分的开发利用提供参考和指导。Hyperuricemia(HUA)and gout are metabolic disorders caused by excessive levels of uric acid in the body.With the continuous improvement of living standards,the prevalence of HUA and gout has risen year after year,and patients with HUA or gout have become younger,posing a great threat to human health.Recent studies have found that certain natural active compounds in edible and medicinal fungi may have remarkable effects in alleviating HUA.This paper reviews the stateof-the-art research on the process of uric acid metabolism,the pathogenesis of HUA and gout,and the mechanisms through which major active components in edible and medicinal fungi regulate uric acid metabolism.The aim of this review is to provide a reference and guidance for the development and utilization of active compounds in edible and medicinal fungi.

关 键 词：高尿酸血症 痛风 尿酸代谢 食药用菌 肠道微生物 

分 类 号：TS209[轻工技术与工程—食品科学]