高分辨质谱-色谱联用技术在食品接触材料迁移物筛查中的应用研究进展  

Recent Progress in the Application of High Resolution Mass Spectrometry for Screening Migrating Substances from Food Contact Materials

作　　者：王国秀 张琦 陆佳 王朝晖 杜振霞 WANG Guoxiu;ZHANG Qi;LU Jia;WANG Zhaohui;DU Zhenxia(Beijing Products Quality Supervision and Inspection Institute,Beijing 101300,China;College of Chemistry,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]北京市产品质量监督检验研究院,北京101300 [2]北京化工大学化学学院,北京100029

出　　处：《食品科学》2025年第7期346-356,共11页Food Science

基　　金：北京市科技计划项目(Z231100004523002)。

摘　　要：在缺乏相关检测方法、质谱数据库及标准品的情况下,对食品接触材料(food contact materials,FCMs)中迁移浓度差异大、种类繁多、结构复杂、来源广泛的迁移物质进行鉴定仍是FCMs安全性评价领域的难点。近年来,高分辨质谱(high resolution mass spectrometry,HRMS)技术以其高灵敏度、高分辨率和高准确性被广泛应用于FCMs迁移物质筛查领域,为解决上述难点提供了强有力的技术支持,逐渐成为FCMs迁移物质筛查及检测的主要手段之一。本文对近几年(2019—2024年)HRMS技术在FCMs迁移物质筛查中的应用进展进行了综述,首先介绍了HRMS技术的基本原理和分类,然后重点分析了该技术在FCMs迁移物质筛查中的最新研究进展。同时,对HRMS技术应用于FCMs迁移物质筛查领域面临的挑战进行了说明,最后对HRMS在FCMs迁移物质筛查领域的发展前景进行了展望。本文旨在通过总结HRMS技术在FCMs迁移物质筛查中的应用现状,为食品安全领域的研究者和实践者提供有价值的参考,促进HRMS技术在食品安全领域的进一步应用和发展。Due to the lack of detection methods,mass spectral databases and reference standards,identifying migrating substances from food contact materials(FCMs)that have wide variations in migration concentrations,high varietal diversity,and complex structures,and come from a wide range of sources remains a challenge in the field of FCMs safety evaluation.In recent years,high resolution mass spectrometry(HRMS),with high sensitivity,resolution,and accuracy,has been widely applied for screening migrating substances from FCMs,providing robust technical support to tackle the aforementioned challenge,and has gradually become a major approach for the screening and detection of migrating substances from FCMs.This article provides a comprehensive review of the progress on HRMS in the screening of migrating substances from FCMs over the past five years(2019–2024).First,the fundamental principle and classification of HRMS are introduced.This review focuses on the state of the art in the application of HRMS for the screening of migrating substances in FCMs.Additionally,it presents the challenges facing this field.Finally,we provide an outlook on future developments.Through this review,we aim to provide valuable insights for researchers and practitioners in the field of food safety and to promote the application and development of HRMS in this field.

关 键 词：高分辨质谱 食品接触材料 迁移物质 迁移物质筛查 

分 类 号：TS206.4[轻工技术与工程—食品科学]