母乳中的活性成分——HMOs对机体的益处及应用现状  

Health Benefits and Application Status of HMOs——a Bioactive Component in Human Milk

作　　者：王司琪 张宇[1] 彭小雨 潘丽娜 周雯婧 汪家琦 李威 张现龙 姜毓君[1] 曲波[1] WANG Siqi;ZHANG Yu;PENG Xiaoyu;PAN Lina;ZHOU Wenjing;WANG Jiaqi;LI Wei;ZHANG Xianlong;JIANG Yujun;QU Bo(Key Lab of Dairy Science,Ministry of Education,College of Food Science,Northeast Agricultural University,Harbin 150030,Heilongjiang,China;Ausnutria Dairy(China)Co.,Ltd.,Changsha 410200,Hunan,China;National Center of Technology Innovation for Dairy,Huhhot 010000,Inner Mongolia,China)

机构地区：[1]东北农业大学食品学院乳品科学教育部重点实验室,黑龙江哈尔滨150030 [2]澳优乳业(中国)有限公司,湖南长沙410200 [3]国家乳业技术创新中心,内蒙古呼和浩特010000

出　　处：《食品研究与开发》2025年第6期191-196,共6页Food Research and Development

基　　金：国家乳业技术创新中心项目(2022⁃开放性课题⁃5)。

摘　　要：母乳低聚糖(human milk oligosaccharides,HMOs)是母乳中重要的生物活性成分之一,是在人乳中唯一存在的第三丰富的固体成分,具有结构和功能的多样性和母体差异性。HMOs已被证明与许多健康益处有关,例如抑制病原体对机体的侵害,促进婴儿肠道微生物组的成熟,增殖婴儿肠道中特定有益菌群——双歧杆菌属,并激活机体的免疫力等多种益生功能。目前,国内已经批准2´⁃岩藻糖基乳糖和乳糖⁃N⁃新四糖两种母乳低聚糖可以应用于婴幼儿配方食品当中,HMOs的益生功能也逐渐受到更多的关注。该文对母乳中含有的重要生物活性分子——HMOs的结构、含量差异和消化特性、对机体健康的益处等进行综述,对HMOs目前的应用现状进行分析并对其未来进行展望。As one of the most important bioactive components in human milk,human milk oligosaccharides(HMOs)are the third most abundant solid components in human milk,with diversity in structure and function and maternal differences.HMOs have been proven to be related to many health benefits,such as inhibiting the invasion of pathogens to the body,promoting the maturity of infant intestinal microflora,proliferating the specific beneficial flora in infant intestinal tract-Bifidobacterium,and activating the immunity of the body.At pres-ent,two kinds of HMOs,2´-fucosyllactose and lactose-n-neotetrase,have been approved to be used in infant formula foods in China,and the probiotic function of HMOs has gradually attracted more attention.This paper reviews the structure,content difference,digestive characteristics and health benefits of HMOs,an important bioactive molecule contained in human milk.The current application status of HMOs was analyzed,and its future development and application were predicted.

关 键 词：母乳低聚糖 母乳活性成分 益生元 健康益处 应用现状 

分 类 号：TS2[轻工技术与工程—食品科学与工程]