The hidden rhythms of epilepsy: exploring biological clocks and epileptic seizure dynamics  

作　　者：Ruili Niu Xuan Guo Jiaoyang Wang Xiaofeng Yang 

机构地区：[1]Guangzhou National Laboratory,Guangzhou 510005,China [2]Department of Neurology,The First Affiliated Hospital,Guangzhou Medical University,Guangzhou 510120,China [3]Guangzhou Medical University,Guangzhou 511436,China

出　　处：《Acta Epileptologica》2025年第1期1-10,共10页癫痫学报(英文)

基　　金：funded by the National Natural Science Foundation of China(XFY 82271492).

摘　　要：Epilepsy,characterized by recurrent seizures,is influenced by biological rhythms,such as circadian,seasonal,and menstrual cycles.These rhythms affect the frequency,severity,and timing of seizures,although the precise mechanisms underlying these associations remain unclear.This review examines the role of biological clocks,particularly the core circadian genes Bmal1,Clock,Per,and Cry,in regulating neuronal excitability and epilepsy susceptibility.We explore how the sleep-wake cycle,particularly non-rapid eye movement sleep,increases the risk of seizures,and discuss the circadian modulation of neurotransmitters like gamma-aminobutyric acid and glutamate.We explore clinical implications,including chronotherapy which refers to the practice of timing medical treatments to align with the body's natural biological rhythms,such as the circadian rhythm.Chronotherapy aligns anti-seizure medication administration with biological rhythms.We also discuss rhythm-based neuromodulation strategies,such as adaptive deep brain stimulation,which may dynamically change stimulation in response to predicted seizures in patients,provide additional therapeutic options.This review emphasizes the potential of integrating biological rhythm analysis into personalized epilepsy management,offering novel approaches to optimize treatment and improve patient outcomes.Future research should focus on understanding individual variability in seizure rhythms and harnessing technological innovations to enhance seizure prediction,precision treatment,and long-term management.

关 键 词：EPILEPSY Biological rhythm Circadian genes CHRONOTHERAPY NEUROMODULATION 

分 类 号：R74[医药卫生—神经病学与精神病学]