Potential inflammatory mechanisms of the ketogenic diet against febrile infection-related epilepsy syndrome  

作　　者：Juan Wang Lingling Xie Li Jiang 

机构地区：[1]Department of Neurology,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,No.136,Zhongshan 2nd Road,Yuzhong District,Chongqing,400014,China [2]Chongqing Key Laboratory of Neurodevelopment and Cognitive Disorders,Chongqing,400014,China

出　　处：《Acta Epileptologica》2025年第1期11-21,共11页癫痫学报(英文)

基　　金：supported by the Youth project of key Laboratory of Ministry of Education(3000971).

摘　　要：Febrile infection-related epilepsy syndrome(FIRES)is a rare epilepsy syndrome with unclear pathogenesis,characterized by fever-induced,super-refractory status epilepticus and high mortality.Studies have shown that ketogenic diet(KD)is effective in controlling convulsions in FIRES,but its mechanisms are unclear.This paper intends to summarize the mechanisms by which KD may exert effects against FIRES.Clinical studies have shown that patients with FIRES have elevated levels of various inflammatory factors such as interleukin(IL)-6,IL-8,IL-10,and so on.KD may exert anti-FIRES effects through several potential inflammatory pathways,including nuclear factor-κB(NF-κB)and NLR family pyrin domain containing 3(NLRP3).Furthermore,the Kyoto Encyclopedia of Genes and Genomes(KEGG)network suggested that KD may play an anti-inflammatory role through several pathways such as cellular senescence and neutrophil extracellular trap formation.These mechanisms need to be further investigated.

关 键 词：Ketogenic diet Febrile infection-related epilepsy syndrome INFLAMMATION MECHANISMS 

分 类 号：R74[医药卫生—神经病学与精神病学]