Mechanism of microglia-mediated neuroinflammation,associated cognitive dysfunction,and therapeutic updates in Alzheimer’s disease  

作　　者：Arpita Ghimire Sayed Abdur Rehman Aleena Subhani Mansoor A Khan Ziyaur Rahman Mohammad Kashif Iqubal Ashif Iqubal 

机构地区：[1]School of Pharmaceutical Education and Research,Jamia Hamdard,New Delhi,India [2]Department of Clinical Research,School of Chemical and Life Sciences,Jamia Hamdard,New Delhi,India [3]Irma Lerma Rangel College of Pharmacy,Texas A&M Health Science Center,Texas A&M University,College Station,Texas,USA [4]Department of Pharmacology,School of Pharmaceutical Education and Research,Jamia Hamdard,New Delhi,India

出　　处：《hLife》2025年第2期64-81,共18页微生物与宿主健康(英文)

摘　　要：Alzheimer’s disease(AD)and associated cognitive dysfunction are major healthcare challenges globally.Various mechanisms of pathogenesis and signaling molecules have been studied for their plausible role in disease initiation and progression.Neuroinflammation has been considered a major hallmark of AD.Amyloid beta(Ab),hyperphosphorylated tau protein,and formed neurofibrillary tangles(NFT)are positively correlated with neuroinflammation.Microglial activation was found to be a key contributor to neuroinflammation,AD pathogenesis,and progression.The mechanism of microglial activation has been studied in detail,and looking into its pivotal role in disease etiology,various drugs have been developed,and many are in the clinical phases of development.These drugs either inhibit the microglial activation or neuroinflammatory event postmicroglial activation.Considering these facts,in the present study,we herein discuss the mechanism of microglial activation and the mechanism of neuroinflammation related to microglial activation and dementia.Here we also discussed the various drugs that either act at tau protein or mitigate neuroinflammation,along with their status in clinical trials.In brief,this review provides an in-depth mechanism of microglial activation and updates on drugs that can inhibit this activation,leading to significant anti-Alzheimer effect and mitigation of cognitive dysfunction.

关 键 词：cognitive dysfunction NEUROINFLAMMATION MICROGLIA oxidative stress and clinical trial 

分 类 号：R74[医药卫生—神经病学与精神病学]