Review of the mechanisms of the biliary-enteric axis in the development of cholangiocarcinoma  

作　　者：Tian-Hao Shen Xue Yu Cheng Zhou Yu Liu Qiu-Ying Li Wei Li Ting-Hui Jiang Yong-Qiang Zhu Yan Liu 

机构地区：[1]Department of Interventional Oncology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China [2]Department of Hepatological Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China

出　　处：《World Journal of Clinical Oncology》2025年第4期44-52,共9页世界临床肿瘤学杂志(英文)

摘　　要：Cholangiocarcinoma(CCA)is a particularly aggressive and challenging type of cancer,known for its poor prognosis,which is worsened by the complex interplay of various biological and environmental factors that contribute to its development.Recently,researchers have increasingly focused on the significant role of the biliary-enteric communication of liver-gut axis in the pathogenesis of CCA,highlighting a complex relationship that has not been thoroughly explored before.This review aims to summarize the key concepts related to the biliary-enteric communication of liver-gut axis and investigate its potential mechanisms that may lead to the onset and progression of CCA,a disease that presents substantial treatment challenges.Important areas of focus will include the microbiome's profound influence,which interacts with host physiology in ways that may worsen cancer development;changes in bile acid metabolism that can create toxic environments favorable for tumor growth;the regulation of inflammatory processes that may either promote or inhibit tumor progression;the immune system's involvement,which is crucial in the body's response to cancer;and the complex interactions within metabolic pathways that can affect cellular behavior and tumor dynamics.By integrating recent research findings from various studies,we aim to explore the multifaceted roles of the biliary-enteric communication of liver-gut axis in CCA,providing new insights and perspectives for future research while identifying promising therapeutic targets that could lead to innovative treatment strategies aimed at improving patient outcomes in this challenging disease.

关 键 词：CHOLANGIOCARCINOMA Biliary-enteric communication of liver-gut axis MICROBIOME Bile acid metabolism Inflammatory response 

分 类 号：R73[医药卫生—肿瘤]