A novel BaEVRless-LV packaging system for the production of lentiviral vectors for clinical-grade CAR-NK cell manufacturing  

作　　者：Yinyin Zhang Minghuan Zhang Mengyuan Li Lihong Zong Qian Ye Wen Lei Wenhai Deng Wenbin Qian 

机构地区：[1]Department of Hematology,the Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou 310009,China [2]Hangzhou RongGu Biotechnology Limited Company,Hangzhou 310056,China [3]Biotherapy Research Center,the Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou 310009,China [4]Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325000,China

出　　处：《Cancer Biology & Medicine》2025年第2期137-143,共7页癌症生物学与医学(英文版)

基　　金：supported by grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(Grant No.2023ZD0501300);Science Technology Department of Zhejiang Province(Grant No.2021C03117);National Natural Science Foundation of China(Grant No.82350104 and 82170219);Natural Science Foundation of Zhejiang Province,China(Grant No.LY23H080004 and LY24H080001);Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(Grant No.2021KY199)。

摘　　要：Chimeric antigen receptor natural killer(CAR-NK)cell therapy is an alternative immunotherapy that provides robust tumor-eliminating effects without inducing life-threatening toxicities and graft-versus-host disease.CAR-NK cell therapy has enabled the development of“off-the-shelf”products that bypass the lengthy and expensive cell manufacturing process1.

关 键 词：LENTIVIRAL packaging VECTORS alternative immunotherapy chimeric antigen receptor natural system cell manufacturing process NOVEL 

分 类 号：R730.51[医药卫生—肿瘤]