LENTIVIRAL

作品数：34被引量：73H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：赵虹赵虹赵庆杰杨子超徐万海更多>>
相关机构：首都医科大学哈尔滨医科大学附属第四医院哈尔滨医科大学北京大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《World Journal of Translational Medicine》《Virologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广西壮族自治区自然科学基金湖北省自然科学基金更多>>
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Phase I clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy
《Science Bulletin》2024年第16期2596-2603,共8页Qiu-Hong Wang Jing Wanga Zhi-Pei Ling Zhi-Qiang Cui Jie Gong Rui Zhang Shi-Jun Li Yang-Yang Wang Rui Yang De-Hui Huang Wen He Jing Gao Chen Feng Pei-Li Hu Li-Ying Liu Lung-Ji Chang Li-Ping Zou 
supported by the Capital’s Funds for Health Improvement and Research(2022-1-5081);the National Key Research and Development Program of China(2023YFC2706304);Shenzhen Geno-Immune Medical Institute;Beijing Meikang Biotechnology Co.,LTD.
This was a single-arm,multicenter,open-label phase I trial.Lentiviral vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodystrophy(CCALD),an...
关键词：ADRENOLEUKODYSTROPHY Lentiviral vectors ABCD1 Intracerebral injection 
Lentiviral Gene Therapy for Artemis-Deficient SCID
《四川生理科学杂志》2022年第12期2107-2107,共1页Morton J Cowan 
Background:The DNA-repair enzyme Artemis is essential for rearrangement of T-and B-cell receptors.Mutations in DCLRE1C,which encodes Artemis,cause Artemis-deficient severe combined immunodeficiency(ART-SCID),which is ...
关键词：SCID IMMUNODEFICIENCY ARTEMIS 
Effect of lentiviral expression of circLIFR on the biological behavior of Hep3B hepatocellular carcinoma cells
《Journal of Hainan Medical University》2022年第24期14-18,共5页LI Chen LIU Lu-zheng LU Han-yuan CHEN Jia-cheng CHEN Liang WU Jin-cai 
Research and Development Key Project of Hainan Province(No.ZDYF2020134,ZDYF2022SHFZ283);the National Natural Science Foundation of China(No.81660489);the Special Research Fund of The Innovation Platform for Academicians of Hannan Province(No.YSPTZX202005);Innovative Research Project for Postgraduates of Hainan Province(No.Hys2020-355)。
Objective:To investigate the effect of lentiviral stable high expression of circLIFR on the biological behavior of Hep3B hepatocellular carcinoma(HCC)cells.Methods:Hep3B cell lines were infected with lentiviral packag...
关键词：Circular RNA circLIFR Hepatocellular carcinoma Biological behavior 
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury被引量：7
《Neural Regeneration Research》2022年第12期2717-2724,共8页Liang Wen Ya-Dong Wang Dong-Feng Shen Pei-Dong Zheng Meng-Di Tu Wen-Dong You Yuan-Run Zhu Hao Wang Jun-Feng Feng Xiao-Feng Yang 
supported by the National Natural Science Foundation of China, Nos.81971159(to LW), 81771317(to JFF)
Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury repair.However,the underlying molecular mechanism remains uncl...
关键词：apoptosis bone marrow mesenchymal stem cells BV2 microglia EXOSOME interleukin 10 lentiviral transfection microRNA-181b NEUROINFLAMMATION phenotype signal transducer and activator of transcription 3 traumatic brain injury 
Calcitonin gene related peptide modified mesenchymal stem cells reduce restenosis after carotid balloon injury in rats
《BIOCELL》2022年第8期1903-1909,共7页PANKE CHEN SHUAI MA 
This work was supported by the Technology Fund of Guizhou Province(Qian ke he LH zi[2014]7576).
This work aimed to investigate the effects of calcitonin gene-related peptide(CGRP)-modified mesenchymal stem cells(MSCs)on vascular stenosis in carotid balloon-injured rats.The CGRP gene labeled with EGFP was transfe...
关键词：Mesenchymal stem cells Calcitonin gene-related peptide Lentiviral transfection Cell transplantation RESTENOSIS 
Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles被引量：2
《Biosafety and Health》2022年第1期38-44,共7页Sheng Wang Lizhen Liu Can Wang Ziqiang Wang Xuhua Duan Gang Chen Hu Zhou Hong Shao 
This work was supported by grants 2020‐SKT‐14 and 2021‐YKT‐01 from the Shanghai Institute for Food and Drug Control;LX‐2021‐06 from the Shanghai Drug Administration;19DZ2294600 from the Shanghai Science and Technology Committee.
The coronavirus disease 2019(COVID‐19)is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2).Therefore,it is necessary ...
关键词：COVID‐19 SARS‐CoV‐2 variants PSEUDOVIRUS Neutralizing antibody RBD 
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy:long-term results from a non-randomised,open-label,phase 1/2 trial and expanded access
《四川生理科学杂志》2021年第11期2002-2002,共1页Francesca Fumagalli 
Background:Effective treatment for metachromatic leukodystrophy(MLD)remains a substantial unmet medical need.In this study we investigated the safety and efficacy of atidarsagene autotemcel(arsa-cel)in patients with M...
关键词：DYSTROPHY diagnosis expanded 
Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction
《Virologica Sinica》2021年第5期981-996,共16页Chu Wang Lina Meng Jialin Wang Kaikai Zhang Sizhu Duan Pengyu Ren Yingzhe Wei Xinyu Fu Bin Yu Jiaxin Wu Xianghui Yu 
funded by the National Natural Science Foundation of China(31270807);the Key Projects in the National Science&Technology Pillar Program in the Thirteenth Five-year Plan Period(2018ZX10731101-002-003 and 2018ZX10731101-001-020);Program for Jilin University Science and Technology Innovative Research Team(JLUSTIRT)(2017TD05);National Postdoctoral Program for Innovative Talents(BX20180124);China Postdoctoral Science Foundation(2018M641786);Science and Technology Development Project of Jilin Province(20200901030SF)。
Human SAMHD1(h SAM)restricts lentiviruses at the reverse transcription step through its d NTP triphosphohydrolase(d NTPase)activity.Besides humans,several mammalian species such as cats and cows that carry their own l...
关键词：SAMHD1 Feline SAMHD1(fSAM) Bovine SAMHD1(bSAM) Nuclear localization signal(NLS) VPX Degradation Viral restriction 
Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury被引量：6
《Neural Regeneration Research》2020年第1期120-127,共8页Mei Yang Jiang-Yang Sun Cheng-Cheng Ying Yong Wang Yong-Lian Guo 
supported by the Natural Science Foundation of Hubei Province of China,No.2017CFB176(to CCY);the Fundamental Research Funds for The Central Hospital of Wuhan of China,No.YB16A01(to CCY)
Cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy.The recovery of erectile function following radical prostatectomy remains challenging.Our previous studies found that in...
关键词：adipose-derived stem cells BRAIN-DERIVED NEUROTROPHIC factor CAVERNOUS nerve injury erectile dysfunction infection intracavernous injection LENTIVIRAL vector neuronal NITRIC oxide synthase radical prostatectomy 
TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts被引量：3
《Neural Regeneration Research》2019年第10期1765-1771,共7页Mei-Ge Zheng Wen-Yuan Sui Zhen-Dan He Yan Liu Yu-Lin Huang Shu-Hua Mu Xin-Zhong Xu Ji-Sen Zhang Jun-Le Qu Jian Zhang Dong Wang 
supported by the National Natural Science Foundation of China,No.81372041(to DW),and No.81801220(to MGZ)
We previously demonstrated that overexpression of tropomyosin receptor kinase A(TrkA)promotes the survival and Schwann celllike differentiation of bone marrow stromal stem cells in nerve grafts,thereby enhancing the r...
关键词：NERVE REGENERATION bone marrow stromal stem cells TROPOMYOSIN RECEPTOR kinase A RECEPTOR LENTIVIRAL vector shRNA extracellular SIGNAL-REGULATED protein kinases 1/2 Bcl-2 NERVE grafts peripheral NERVE REGENERATION survival neural REGENERATION 
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