Background:The DNA-repair enzyme Artemis is essential for rearrangement of T-and B-cell receptors.Mutations in DCLRE1C,which encodes Artemis,cause Artemis-deficient severe combined immunodeficiency(ART-SCID),which is ...
In the ARTEMIS-CTONG1509 multicenter phase 3 study recently published in Cancer Cell,Zhou et al.investigate the combination of the EGFR tyrosine kinase inhibitor(TKI)erlotinib and anti-angiogenic bevacizumab in treatm...