乙醇降解微生物及其解酒产品的研究进展  

Research progress on ethanol-degrading microorganisms and their anti-alcohol products

作　　者：曹敬华[1] 李恬心 刘锐[1] 朱正军[1] 李立 汪江波[1] CAO Jinghua;LI Tianxin;LIU Rui;ZHU Zhengjun;LI Li;WANG Jiangbo(Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),Key Laboratory of Fermentation Engineering(Ministry of Education),Hubei Key Laboratory of Industrial Microbiology,School of Life and Health Sciences,Hubei University of Technology,Wuhan 430068,China;Hubei Lingjiaozhou Ecological Technology Co.,Ltd.,Wuhan 430030,China)

机构地区：[1]湖北工业大学生命科学与健康工程学院工业发酵省部共建协同创新中心发酵工程教育部重点实验室工业微生物湖北省重点实验室,湖北武汉430068 [2]湖北菱角洲生态科技有限公司,湖北武汉430030

出　　处：《中国酿造》2025年第4期27-32,共6页China Brewing

基　　金：湖北省重点研发计划项目(2021BGD016);湖北省揭榜制科技项目(2023BEB035)。

摘　　要：酒精中毒是由于人体摄入过多乙醇,短时间内无法充分代谢而引起的疾病。急性酒精中毒会造成大脑功能障碍,甚至导致死亡,慢性酒精中毒与心脑血管疾病、肝脏疾病等代谢疾病存在密切关系。通过微生物干预乙醇代谢是一种潜在的安全、经济、高效的方法,乙醇降解微生物能够通过产酶和促进机体酶类表达而代谢乙醇,或者通过恢复肠道菌群稳态,降低肠道的通透性来抑制乙醇的吸收,还能促进机体抗氧化从而减少酒精性肝损伤。该文对微生物降解乙醇的途径、特性以及相关解酒产品的作用特点进行综述,以期为后续研究提供理论基础。Alcoholism is a disease resulting from excessive ethanol intake and inadequate metabolism within a short period of time.Acute alcoholism can lead to brain dysfunction and even fatality,while chronic alcoholism is closely associated with metabolic disorders such as cardiovascular and cerebrovascular diseases,as well as liver diseases.The intervention of ethanol metabolism through microorganisms presents a potentially safe,cost-effective,and efficient approach.Ethanol-degrading microorganisms have the ability to metabolize ethanol by producing enzymes and enhancing en-zyme expression in the body,or they can inhibit ethanol absorption by restoring intestinal flora homeostasis,reducing intestinal permeability,and pro-moting antioxidant activity to mitigate alcoholic liver injury.The ways,characteristics of microbial degradation of ethanol and the function and char-acteristics of related anti-alcohol products were reviewed,aiming to establish a theoretical foundation for future research.

关 键 词：乙醇 降解 微生物 解酒产品 解酒机制 

分 类 号：TS261.2[轻工技术与工程—发酵工程]