Arachidonate 15-lipoxygenase:A promising therapeutic target for alleviating inflammation in acute pancreatitis  

作　　者：Duygu Kirkik Sevgi Kalkanli Tas 

机构地区：[1]Department of Immunology,Hamidiye Medicine Faculty,University of Health Sciences,Istanbul 34668,Türkiye [2]Department of Medical Biology,Hamidiye Medicine Faculty,University of Health Sciences,Istanbul 34668,Türkiye

出　　处：《World Journal of Gastroenterology》2025年第15期131-135,共5页世界胃肠病学杂志(英文)

摘　　要：This article discusses the significant findings from the study on the transfection of arachidonate 15-lipoxygenase(ALOX15)and its therapeutic potential in managing acute pancreatitis(AP).The research highlights the role of ALOX15 in attenuating inflammatory responses,apoptosis,and autophagy in a ceruleininduced AP murine model.By using a recombinant lentiviral vector for efficient gene delivery,the study provides compelling evidence for the protective effects of ALOX15 transfection on pancreatic tissue.The authors demonstrate that ALOX15 reduces the expression of key inflammatory markers like interleukin-βand tumor necrosis factorαwhile promoting apoptosis through caspase-3 activation.Furthermore,the modulation of autophagy and structural preservation of pancreatic acinar cells suggest that ALOX15 could be a promising therapeutic target for AP.The implications of these findings are discussed,emphasizing the potential for future clinical translation and further research to explore the molecular mechanisms and therapeutic applications of ALOX15 in inflammatory diseases.

关 键 词：Acute pancreatitis Arachidonate 15-lipoxygenase INFLAMMATION APOPTOSIS AUTOPHAGY 

分 类 号：R576[医药卫生—消化系统]