海洋副产物来源生物肽提取、纯化及生物利用度研究进展  

Research Progress on the Extraction,Purification and Bioavailability of Bioactive Peptides Derived from Marine By-products

作　　者：贺玉珊 刘爱国[2] 丛海花 吴琼 徐亦涌 HE Yushan;LIU Aiguo;CONG Haihua;WU Qiong;XU Yiyong(College of Food and Drug,Shanghai Zhongqiao University of Vocational Technology,Shanghai 200540,China;School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China;School of Food Science and Technology,Dalian Polytechnic University,National Engineering Research Center of Seafood,State Key Lab of Marine Food Processing&Safety Control,Dalian 116034,China)

机构地区：[1]上海中侨职业技术大学食品药品学院,上海200540 [2]天津商业大学生物技术与食品科学学院,天津300134 [3]大连工业大学食品学院,国家海洋食品工程技术研究中心,海洋食品加工与安全控制全国重点实验室,辽宁大连116034

出　　处：《保鲜与加工》2025年第4期144-156,共13页Storage and Process

基　　金：国家自然科学基金青年科学基金项目(31701630);上海市“揽蓄计划”B类人才项目(z32010.22.01)。

摘　　要：海洋副产物是渔业加工中的重要废弃资源,也是具有功能活性的“蓝色食物”的重要来源。近年来,随着对海洋生物资源的深入挖掘,海洋副产物中的生物活性肽因具有抗氧化、抗高血压、抗凝血等多种生物活性,受到广泛关注。综述了海洋副产物来源生物活性肽的提取与分离技术及其潜在的生物活性,特别关注了生物活性肽的生物利用度问题,并分析了影响生物活性肽体内吸收、稳定性及代谢过程的因素。此外,还探讨了提升生物利用度的相关技术,如微胶囊化和分子结构优化。分析发现,尽管海洋副产物肽在功能性食品和药物开发中的应用潜力巨大,但提高其生物利用度仍面临挑战。未来的研究应重点关注如何进一步优化提取工艺、提高生物肽的生物利用度,并通过创新技术提升其在体内的生物效能。通过探讨海洋生物活性肽的研究进展,旨在为海洋副产物生物活性肽的开发与应用提供新的思路与参考,以促进“蓝色食物”的持续创新和发展。Marine by-products serve as a valuable waste resource in fishery processing and a significant source of functionally active‘Blue Food’.In recent years,with the in-depth exploration of marine biological resources,bioactive peptides derived from marine by-products have attracted widespread attention due to their various biological activities,including antioxidant,anti-hypertensive,and anticoagulant effects.While reviewing the extraction and separation techniques for bioactive peptides derived from marine by-products and their potential biological activities,paying special attention to the bioavailability of bioactive peptides,and analyzing the factors affecting the in vivo absorption,stability and metabolic processes of bioactive peptides.Furthermore,this paper discussed related technologies for enhancing bioavailability,such as microencapsulation and molecular structure optimization.The analysis reveals that although marine by-product peptides have great potential for application in functional foods and drug development,their efficient utilization still faces technical challenges.Future research should focus on further optimizing the extraction processes,improving the bioavailability of bioactive peptides,and enhancing their biological efficacy in vivo through innovative technologies.By discussing the research progress of bioactive peptides from marine by-products,this work aims to provide new ideas and references for the development and application of bioactive peptides from marine by-products,promoting the continuous innovation and development of‘Blue Food’.

关 键 词：海洋副产物 生物活性肽 提取 纯化 生物利用度 

分 类 号：TS209[轻工技术与工程—食品科学]