Bt水稻“克螟稻”稻米毒理性评价研究初报  

A Preliminary Study on Toxicological Evaluation of Transgenic Rice Flour with a Synthetic cry1Ab Gene from Bacillus thuringiensis

作　　者：王忠华[1] 王茵[2] 崔海瑞[1] 舒庆尧[1] 夏英武[1] 

机构地区：[1]浙江大学原子核农业科学研究所,杭州310029 [2]浙江省医学科学院,杭州310013

出　　处：《中国农业科学》2002年第12期1487-1492,共6页Scientia Agricultura Sinica

基　　金：国家植物转基因专项资助项目 (J2 0 0 0 B 0 0 9) ;浙江省科委重大资助项目 (99110 2 0 0 4 0 0 2 );美国洛氏基金资助项目 (2 0 0 0FS0 2 0 )

摘　　要：经大鼠急性中毒试验确定 ,转Bt基因抗虫水稻稻米属无毒级。大鼠 90d喂养结果显示 ,各试验组大鼠体重、进食量和食物利用率与对照组均无显著差异。对大鼠肝、肾、胃、肠及睾丸进行组织切片检查 ,均未见病理性改变。大鼠脏体比、血象及血生化指标均在正常范围内 ,试验组与对照组无明显差异。Rice seed flour containing Cry1Ab protein from Bt transgenic rice plants resistant to insects was subjected to an acute toxicity test with rats.Results showed that the Bt transgenic rice was of the 'nontoxic class'. No marked differences in appearance, body weight, food intake and feed utilization rate were observed between all treated groups and the control in a 90 day feeding test with rats. In addition, no pathological changes were found in organs such as liver, kidney,stomach,intestines and testes of rats in both treated and control groups by histological section examination. No signifcant differences(P>0.05) were observed in organ relative weight, hemogram and the blood indexes of rats between the treated groups and the control.

关 键 词：BT水稻 克螟稻 稻米 毒理性评价 转Bt抗虫稻 毒性试验 食品安全性 

分 类 号：S511[农业科学—作物学] TS201.6[轻工技术与工程—食品科学]