Potential role of tetrandrine in cancer therapy  

作　　者：CHEN Yu-JenDepartment of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan 104, Department of Martial Arts, Chinese Culture University, Taipei, Taiwan 111, China 

出　　处：《Acta Pharmacologica Sinica》2002年第12期1102-1106,共5页中国药理学报（英文版）

基　　金：Projected supported by the National Science Council(grant 91-2314-B-195-009).

摘　　要：Tetrandrine,a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore,exhibits very broad pharmacological actions,including anti-tumor activity.The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization,multidrug resistance,normal tissue radioprotection,and angiogenesis are most promising and deserve great attention.Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy.to evaluate the potential clinical efficacy of tetrandrine for cancer therapy,more mechanism-based pharmacological,pharmacokinetic,and pharmacodynamic studies are required.Tetrandrine, a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore, exhibits very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy. To evaluate the potential clinical efficacy of tetrandrine for cancer therapy, more mechanism-based pharmacological, pharmacokinetic, and pharmacodynamic studies are required.

关 键 词：Drug Resistance  Multiple Drug Resistance  Neoplasm ALKALOIDS Animals Antineoplastic Agents  Phytogenic Apoptosis BENZYLISOQUINOLINES Cell Division Humans Research Support  Non-U.S. Gov't Tumor Cells  Cultured 

分 类 号：R730.5[医药卫生—肿瘤]