BENZYLISOQUINOLINES

作品数：7被引量：89H指数：3
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相关作者：李卓刘杰文朱惠芳张金红王彤更多>>
相关机构：中国医学科学院北京协和医学院南开大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金天津市自然科学基金更多>>
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Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action被引量：33
《Acta Pharmacologica Sinica》2002年第12期1057-1068,共12页KwanCY AchiF 
Tetrandrine (TET), a bis-benzylisoquinoline alkaloid purified and identified an active ingredient in a Chinese medicinal herb, radix stephanae tetrandrae, has been used traditionally for the treatment of congestive ci...
关键词：Adrenal Glands Alkaloids Animals Antihypertensive Agents BENZYLISOQUINOLINES Calcium Channel Blockers Endothelium  Vascular Humans Molecular Structure Plants  Medicinal Receptors  Adrenergic  alpha Research Support  Non-U.S. Gov't Stephania VASOCONSTRICTION Vasodilator Agents 
Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases被引量：19
《Acta Pharmacologica Sinica》2002年第12期1093-1101,共9页LAI Jenn-HaungRheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China 
Project supported by National Health Research Institutes,Taiwan,China.(NHRI-GT-EX89B915C)and Tri-Service General Hospital(TSGH-C91-13).
Autoimmune diseases characterized by activation of immune effector cells and damage of target organs are currently treated with a combination of several disease-modifying antirheumatic drugs (DMARDs) that preserve dif...
关键词：Alkaloids Animals Apoptosis Arthritis  Rheumatoid Autoimmune Diseases BENZYLISOQUINOLINES Humans Immunosuppressive Agents Lymphocyte Activation Research Support  Non-U.S. Gov't T-LYMPHOCYTES 
Potential role of tetrandrine in cancer therapy被引量：38
《Acta Pharmacologica Sinica》2002年第12期1102-1106,共5页CHEN Yu-JenDepartment of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan 104, Department of Martial Arts, Chinese Culture University, Taipei, Taiwan 111, China 
Projected supported by the National Science Council(grant 91-2314-B-195-009).
Tetrandrine,a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore,exhibits very broad pharmacological actions,including anti-tumor activity.The beneficial effects of tetrandrine o...
关键词：Drug Resistance  Multiple Drug Resistance  Neoplasm ALKALOIDS Animals Antineoplastic Agents  Phytogenic Apoptosis BENZYLISOQUINOLINES Cell Division Humans Research Support  Non-U.S. Gov't Tumor Cells  Cultured 
Effects of tetrandrine on smooth muscle contraction induced by mediators in pulmonary hypertension被引量：2
《Acta Pharmacologica Sinica》2002年第12期1114-1120,共7页WANG Huai-Liang, ZHANG Xin-Hua, CHANG Tian-HuiDepartment of Clinical Pharmacology, China Medical University, Shenyang 110001, China 
Projects supported by National Natural Science Foundation of China.№ 39170846.
AIM: In attempt to characterize tetrandrine on pulmonary hypertension, biological activities induced by a range of mediators implicated in the pathogenesis of pulmonary hypertension were investigated. METHODS: Pulmona...
关键词：15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid 3-Pyridinecarboxylic acid  1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-  Methylester Alkaloids Angiotensin II Animals Antihypertensive Agents BENZYLISOQUINOLINES Endothelin-1 Guinea Pigs Hypertension  Pulmonary Male Muscle Contraction Muscle  Smooth  Vascular Neuropeptide Y Pulmonary Artery RATS Rats  Sprague-Dawley Research Support  Non-U.S. Gov't SRS-A 
Characterization of a novel tetrandrine-induced contraction in rat tail artery
《Acta Pharmacologica Sinica》2002年第8期698-704,共7页AchikeFI KwanCy 
AIM: In an attempt to pharmacologically characterize the Chinese antihypertensive drug, tetrandrine, we observed in rat-tail arteries, an unusual contraction in tissues that were stimulated with high [KCl] and not tho...
关键词：BENZYLISOQUINOLINES ALKALOIDS Animals ARTERIES Male Muscle Contraction Muscle  Smooth  Vascular PHENYLEPHRINE Potassium Chloride RATS Rats  Sprague-Dawley Tail 
The Effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo被引量：2
《Chinese Medical Journal》2002年第5期759-762,157,共4页刘杰文 齐淑玲 朱惠芳 李卓 王彤 张金红 
ThisProjectwassupportedbyTianjinnaturalfoundationofsciences(9414 0 90 17);theMinisterofPublicHealthofChina (94 2 0 2 4)
OBJECTIVE: To evaluate the anti-hepatoma effect of Calmodulin antagonist 0 - 4-ethoxyl-butyl-Berbamine (EBB), one of the berbamine derivatives. METHODS: Monotetrazolium (MTT) method was used to analyze the effect of E...
关键词：BENZYLISOQUINOLINES Alkaloids Animals Antimetabolites  Antineoplastic CALMODULIN Carcinoma  Hepatocellular Cell Division Cell Survival Chromatography  Thin Layer Dose-Response Relationship  Drug Drug Synergism Fluorouracil Inhibitory Concentration 50 Liver Neoplasms  Experimental Mice Neoplasm Transplantation RNA  Messenger Research Support  Non-U.S. Gov't Tumor Cells  Cultured Tumor Suppressor Protein p53 
Pharmacology of tetrandrine and its therapeutic use in digestive diseases被引量：3
《World Journal of Gastroenterology》2001年第5期627-629,共3页Ding-Guo Li Zhi-Rong Wang Han-Ming Lu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China 
INTRODUCTIONTetrandrine (Tet) is a dibenzylisoquinoline alkaloid isolatedfrom Stephania tetrandra S. Moore, a Chinese herbalmedicine. In the past decade, lots of studies demonstrated that Tet has multiple bioactivitie...
关键词：BENZYLISOQUINOLINES ALKALOIDS Anti-Inflammatory Agents  Non-Steroidal Drugs  Chinese Herbal Gastrointestinal Diseases Humans 
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