CALMODULIN

作品数:136被引量:249H指数:9
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相关领域:生物学更多>>
相关作者:郭兆贵黄韶玲郭迅刘文兰丁波更多>>
相关机构:中国医科大学湖南医科大学南京师范大学中国医学科学院北京协和医学院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划河北省自然科学基金国家高技术研究发展计划更多>>
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Calmodulins and calmodulin-like proteins-mediated plant organellar calcium signaling networks under abiotic stress被引量:1
《The Crop Journal》2024年第5期1321-1332,共12页Shuang Liu Liyan Zhao Maozi Cheng Jinfeng Sun Xiaomeng Ji Aman Ullah Guosheng Xie 
supported by the National Science Foundation of China (32171941,31571583)。
Plant calmodulins(CaMs)and calmodulin-like proteins(CMLs)mediate Ca~(2+)signaling in response to abiotic stresses.Manipulation of this signaling in crops could increase stress tolerance.We review methods for detecting...
关键词:Abiotic stress CALMODULIN Calmodulin-like protein Organellar calcium signaling pathway 
Developmental endothelial locus-1 enhances ER calmodulin expression,mitigates ER stress,suppresses inflammation,and attenuates neuronal apoptosis
《Journal of Chinese Pharmaceutical Sciences》2024年第9期795-804,共10页Hao Wang Kangxue Chen Yuyan Zhang Kuijun Jiang Zhonglei Sun 
National Key Research and Development Plan of China(Grant No.2016YFC1101503)。
This study aimed to investigate the impact of developmental endothelial locus-1(Del-1)on sarcoplasmic reticulum Ca^(2+)ATPase 2(SERCA2)and its potential effects on spinal cord injury(SCI).A total of 48 mice were rando...
关键词:SCI Del-1 SERCA2 INFLAMMATION Apoptosis 
Neurological consequences of human calmodulin mutations
《Neural Regeneration Research》2024年第5期943-944,共2页Helene H.Jensen Anders Olsen 
supported by Lundbeckfonden(R250-2017-134,to HHJ).
When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream...
关键词:consequences unchanged CALMODULIN 
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis
《Acta Pharmaceutica Sinica B》2024年第4期1605-1623,共19页Zhifeng Huang Tongtong Pan Liang Xu Lu Shi Xiong Ma Liya Zhou Luyao Wang Jiaojiao Wang Guoqing Zhu Dazhi Chen Lingtao Song Xiaomin Pan Xiaodong Wang Xiaokun Li Yongde Luo Yongping Chen 
We appreciate the financial support from the National Natural Science Foundation of China(82070593,92057122,80223003,82002965 to Yongping Chen,Zhifeng Huang,Xiaokun Li,and Lintao Song);Key Project of Zhejiang Provincial Natural Science Foundation(LD21H030002,DQ24H310001 to Yongping Chen and Zhifeng Huang,China);Key Project from Science Technology Department of Wenzhou(ZY2021022 to Zhifeng Huang,China).
Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatop...
关键词:Fibroblast growthfactor 4 Fibroblast growth factor receptor 4 Immune liver injury Ca^(2+)/Calmodulin dependent protein 
Downregulated calmodulin expression contributes to endothelial cell impairment in diabetes
《Acta Pharmacologica Sinica》2023年第12期2492-2503,共12页Tian-tian Liu Huan-huan Xu Ze-juan Liu He-ping Zhang Hai-tao Zhou Zhi-xiang Zhu Zhi-qiang Wang Jing-yi Xue Qiang Li Yi Ma Hong-jie You Da-li Luo 
the National Natural Science Foundation of China(81570206 and 81970197);the Scientific Research Key Program of Beijing Municipal Commission of Education(KZ201710025023).
Endothelial dysfunction,a central hallmark of cardiovascular pathogenesis in diabetes mellitus,is characterized by impaired endothelial nitric oxide synthase(eNOS)and NO bioavailability.However,the underlying mechanis...
关键词:diabetes mellitus CALMODULIN endothelial nitric oxide synthase angiogenesis endothelial progenitor cell hind limb ischemia 
Calmodulin B-like interacting protein kinase 31:A novel target to improve resistance to sheath blight and the stability of yield in rice
《Crop Design》2023年第2期68-70,共3页Huan Chen Zhuo Li Yuan Hu Xuan 
supported by the National Natural Science Foundation of China(32072406);the Nature Science Foundation of Liaoning(2020-YQ-05).
Rice(Oryza sativa L.)is a crucial cereal crop that plays a significant role in the global food supply[1].However,rice production is threatened by various biotic and abiotic stresses,including sheath blight(ShB),which ...
关键词:CIPK31 Sheath blight RESISTANCE YIELD Balance RICE 
Calcium/calmodulin modulates salt responses by binding a novel interacting protein SAMS1 in peanut(Arachis hypogaea L.)被引量:1
《The Crop Journal》2023年第1期21-32,共12页Sha Yang Jianguo Wang Zhaohui Tang Yan Li Jialei Zhang Feng Guo Jingjing Meng Feng Cui Xinguo Li Shubo Wan 
supported by the National Key Technology Research and Development Program of China (2018YFD1000900);the Natural Science Foundation of Shandong Province(ZR2020MC094);the Natural Science Foundation of Shandong Province (ZR2021QC163);Special Funds for Local Science and Technology Development Guided by the Central Committee(YDZX20203700001861)。
The Ca^(2+)/CaM signal transduction pathway helps plants adapt to environmental stress. However, our knowledge on the functional proteins of C^(2+)/CaM pathway in peanut(Arachis hypogeae L.) remains limited. In the pr...
关键词:AhCaM4 AhSAMS1 Protein interaction Polyamines Salt tolerance 
Overexpression of a sugarcane ScCaM gene negatively regulates salinity and drought stress responses in transgenic Arabidopsis thaliana
《BIOCELL》2023年第1期215-225,共11页JINXIAN LIU JINGFANG FENG CHANG ZHANG YONGJUAN REN WEIHUA SU GUANGHENG WU XIANYU FU NING HUANG YOUXIONG QUE HUI LING JUN LUO 
This research was funded by the Natural Science Foundation of Fujian Province,China(2018J01470 and 2021J01137);Scientific research projects of introducing talents in Wuyi University(YJ202109);Special fund for scientific and technological innovation of Fujian Agriculture and Forestry University(CXZX2020081A);China Agriculture Research System of MOF and MARA(CARS-17);The funders had no role in the study design,data collection,and analysis,decision to publish,or preparation of the manuscript.
Calmodulin(CaM)proteins play a key role in signal transduction under various stresses.In the present study,the effects of a sugarcane ScCaM gene(NCBI accession number:GQ246454)on drought and salt stress tolerance in t...
关键词:Calmodulin(CaM) Signal transduction Drought Salt stress SUGARCANE 
CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation
《Journal of Molecular Cell Biology》2022年第7期49-61,共13页Yan Zhang Emily A.Daniel July Metcalf Yuqiao Dai Gail A.Reif Darren P.Wallace 
National Institute of Diabetes and Digestive and Kidney Disease(R01DK081579 to D.P.W.);fellowship grants from the PKD Foundation(to Y.Z.);Kansas Idea Network of Biomedical Research Excellence(K-INBRE,P20 GM103418 to Y.Z.).
Autosomal dominant polycystic kidney disease(ADPKD)is characterized by progressive enlargement of fluid-filled cysts,causing nephron loss and a decline in renal function.Mammalian target of rapamycin(mTOR)is overactiv...
关键词:ADPKD CaMK4 CaMKKβ CALMODULIN LKB1 AMPK 
Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury被引量:1
《World Journal of Diabetes》2022年第4期338-357,共20页Shi-Jun Jiang 
BACKGROUND Diabetic cardiomyopathy(DCM) is a serious complication of end-stage diabetes that presents symptoms such as cardiac hypertrophy and heart failure. The transient receptor potential channel 6(TRPC6) protein i...
关键词:Diabetic cardiomyopathy Apoptosis PROLIFERATION H9C2 cells Transient receptor potential channel 6 P-calmodulin dependent protein kinaseⅡ 
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