supported by the National Science Foundation of China (32171941,31571583)。
Plant calmodulins(CaMs)and calmodulin-like proteins(CMLs)mediate Ca~(2+)signaling in response to abiotic stresses.Manipulation of this signaling in crops could increase stress tolerance.We review methods for detecting...
National Key Research and Development Plan of China(Grant No.2016YFC1101503)。
This study aimed to investigate the impact of developmental endothelial locus-1(Del-1)on sarcoplasmic reticulum Ca^(2+)ATPase 2(SERCA2)and its potential effects on spinal cord injury(SCI).A total of 48 mice were rando...
supported by Lundbeckfonden(R250-2017-134,to HHJ).
When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream...
We appreciate the financial support from the National Natural Science Foundation of China(82070593,92057122,80223003,82002965 to Yongping Chen,Zhifeng Huang,Xiaokun Li,and Lintao Song);Key Project of Zhejiang Provincial Natural Science Foundation(LD21H030002,DQ24H310001 to Yongping Chen and Zhifeng Huang,China);Key Project from Science Technology Department of Wenzhou(ZY2021022 to Zhifeng Huang,China).
Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatop...
the National Natural Science Foundation of China(81570206 and 81970197);the Scientific Research Key Program of Beijing Municipal Commission of Education(KZ201710025023).
Endothelial dysfunction,a central hallmark of cardiovascular pathogenesis in diabetes mellitus,is characterized by impaired endothelial nitric oxide synthase(eNOS)and NO bioavailability.However,the underlying mechanis...
supported by the National Natural Science Foundation of China(32072406);the Nature Science Foundation of Liaoning(2020-YQ-05).
Rice(Oryza sativa L.)is a crucial cereal crop that plays a significant role in the global food supply[1].However,rice production is threatened by various biotic and abiotic stresses,including sheath blight(ShB),which ...
supported by the National Key Technology Research and Development Program of China (2018YFD1000900);the Natural Science Foundation of Shandong Province(ZR2020MC094);the Natural Science Foundation of Shandong Province (ZR2021QC163);Special Funds for Local Science and Technology Development Guided by the Central Committee(YDZX20203700001861)。
The Ca^(2+)/CaM signal transduction pathway helps plants adapt to environmental stress. However, our knowledge on the functional proteins of C^(2+)/CaM pathway in peanut(Arachis hypogeae L.) remains limited. In the pr...
This research was funded by the Natural Science Foundation of Fujian Province,China(2018J01470 and 2021J01137);Scientific research projects of introducing talents in Wuyi University(YJ202109);Special fund for scientific and technological innovation of Fujian Agriculture and Forestry University(CXZX2020081A);China Agriculture Research System of MOF and MARA(CARS-17);The funders had no role in the study design,data collection,and analysis,decision to publish,or preparation of the manuscript.
Calmodulin(CaM)proteins play a key role in signal transduction under various stresses.In the present study,the effects of a sugarcane ScCaM gene(NCBI accession number:GQ246454)on drought and salt stress tolerance in t...
National Institute of Diabetes and Digestive and Kidney Disease(R01DK081579 to D.P.W.);fellowship grants from the PKD Foundation(to Y.Z.);Kansas Idea Network of Biomedical Research Excellence(K-INBRE,P20 GM103418 to Y.Z.).
Autosomal dominant polycystic kidney disease(ADPKD)is characterized by progressive enlargement of fluid-filled cysts,causing nephron loss and a decline in renal function.Mammalian target of rapamycin(mTOR)is overactiv...
BACKGROUND Diabetic cardiomyopathy(DCM) is a serious complication of end-stage diabetes that presents symptoms such as cardiac hypertrophy and heart failure. The transient receptor potential channel 6(TRPC6) protein i...