反丁烯二酸葡萄糖甲酯的合成及抑菌活性研究  

Synthesis of glucosyl methyl fumarate and its antimicrobial activity

作　　者：战宇[1] 郭新竹[1] 宁正祥[1] 

机构地区：[1]华南理工大学食品与生物工程学院,广东广州510641

出　　处：《广东药学院学报》2003年第2期141-143,149,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：以α,β-不饱和羰基结构为母体合成对皮肤无致敏性的反丁烯二酸葡萄糖甲酯(GMF)。合成实验结果表明:顺丁烯二酸酐与甲醇的摩尔比为1.1:1时,单甲酯的产率最高;异构化催化剂选用反丁烯二酸单甲酯单酰氯;酰化反应中亚硫酰氯与反丁烯二酸单甲酯的摩尔比为 6:1,在100℃下反应40 min时得率最高;GMF的酯化度与其抑菌能力直接相关,反丁烯二酸单甲酯单酰氯:葡萄糖=4 mol:1 mol,70℃条件下,反应60min达到最佳抑菌酯化度2.8。The Glucosyl Methyl Fumarate(GMF) was synthesized. The optimum technology condition was; maleic anhydride : methol = 1.1 mol : 1 mol; with fumaric acid monomethyl monochloride (FMMC) as isomerization activator; monomethyl fumatate and thioyl chloride (molar ratio 1:6) reacted at 100μ for 40 minutes. The antimicrobial activity of GMF was directly correlated with the degree of esterification (DE). Under the condition of FMMC : glucose = 4 mol : 1 mol and reacted at 70 μ for 60 minutes, the GMF ( DE = 2.8) exhibited the highest antimicrobial activity.

关 键 词：反丁烯二酸葡萄糖甲酯 合成 抑菌活性 研究 催化剂 

分 类 号：R914[医药卫生—药物化学] R96[医药卫生—药学]